Sulaieva, OksanaDudin, OleksandrMinster, OzarKobyliak, Nazarii2024-12-122024-12-122023-12-21Dudin O, Mintser O, Kobyliak N, Kaminskyi D, Shabalkov R, Matvieieva A, Sukhanova O, Kalmykova A, Kozakov D, Mashukov A, Sulaieva O. Incidence of BRAF mutations in cutaneous melanoma: histopathological and molecular analysis of a Ukrainian population. Melanoma Manag. 2023 Dec 21;10(1):MMT64. doi: 10.2217/mmt-2023-0005. PMID: 38221928; PMCID: PMC10784762.10.2217/mmt-2023-0005https://ir.kmu.edu.ua/handle/123456789/611Aim: This study aimed to investigate the incidence of BRAF mutation in cutaneous melanoma in theUkrainian population with respect to clinical and histopathological data. Materials & methods: This single-center retrospective cohort study enrolled 299 primary CM with known BRAF status assessed by RT-PCR.Results: The overall BRAF mutation rate was 56.5% in CM and demonstrated a link with the younger age(p < 0.001), anatomical site (p < 0.001) and histological type of CM (p = 0.022). BRAF-positive CM possesseda slightly higher mitotic rate (p = 0.015) and Breslow thickness (p = 0.028) but did not relate to tumor-infiltrating lymphocytes. Conclusion: The high rate of BRAF mutations in CM patients in the Ukrainiancohort was associated with superficial spreading histology, higher depth of invasion and proliferation.en-USBRAF-mutationscutaneous melanomahistological subtypeprognosis predictionArticle