Кафедра фармакології, клінічної фармакології, патологічної фізіології

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Browsing Кафедра фармакології, клінічної фармакології, патологічної фізіології by Author "Hameed M."

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    COMMUNITIES AND ATTITUDES ON THE USE OF HERBAL REMEDIES IN THE TREATMENT OF COVID-19: A REVIEW
    (SCIENTIFIC-DISCUSSION, 2024-07-06) Parchami Ghazaee S.; Marchenko-Tolsta K.; Novykova L.; Hameed M.
    The established antiviral properties exhibited by certain medicinal plants, coupled with additional advantages such as minimal adverse effects and cost-effectiveness, have elicited a heightened inclination among the public towards natural therapies for the management of diseases. Amid the COVID-19 pandemic, anecdotal reports from residents across seven countries in Latin America and the Caribbean (LAC) underscore the inclination of healthcare professionals and spiritual leaders to recommend specific medicinal plant interventions. Notably, Zin- giber officinale, Curcuma angustifolia, and Allium sativum emerge as frequently cited species employed by com- munities in Nepal, with Zingiber officinale Rosc., honey (Mel), garlic (Allium sativum L.), and perilla (Perilla frutescens (L.) Britt.) being prevalent herbal remedies in Vietnamese communities, especially for addressing res- piratory symptoms associated with COVID-19. The observed self-administration of these herbal medicines may serve as a catalyst, motivating researchers within the pharmaceutical industry to conduct comprehensive scientific assessments to validate their efficacy, reliability, and optimal dosage.
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    Role of phytochemicals treatments in managing rheumatoid arthritis (review article)
    (Видавничий дім «Гельветика», 2023-05-29) Parchami Ghazaee S.; Harnyk T.; Gorova E.; Sereda P.; Marchenko-Tolsta K.; Hameed M.
    Non-steroidal anti-inflammatory drugs are one of the symptomatic treatment options for rheumatoid arthritis (RA). However, these medications are known to have multiple adverse effects. Although biological medications target molecular pathways involved in the inflammatory process of RA, there is a lack of long-term safety data. This review aims to present the novel insights of recent studies investigating medicinal plants, phytochemicals and their pharmacological activities against RA. Punicalagin reduces release of LPS-induced nitric oxide, TNF-α, and IL-6 by suppressing NF-κB and MAPK signaling pathways that are responsible for apoptosis of chondrocytes. Anthocyanins decrease the number of Th17 cells and suppress Th17 cells differentiation in vivo and in vitro. Also, anthocyanins inhibit osteoclasts via downregulation of cytokines including IL-1, IL-6, IL-17, and TNF-α in vitro. Oral ellagic acid in arthritic rats considerably decreases paw edema and levels of chitinase-3-like protein-1, which is induced via the NF-κB pathway and overexpression of which is associated with the inflammatory process of RA in chondrocytes and synovial tissue. Punicic acid reduces MMP9 gene expression, associated with the activation of NF-κB, which may mediate its anti-inflammatory effect in osteoarthritis. Although to date natural products are mainly used as nutraceuticals, the treatment of RA by medicinal plants needs more investigation to fully explore their potential as pharmacological agents in the treatment of autoimmune inflammatory diseases.