Browsing by Author "Odintsova Tetiana"

Now showing 1 - 7 of 7

COGNITIVE FUNCTIONS IN MULTIPLE SCLEROSIS PATIENTS DEPENDING ON THE DIFFERENT RISK FACTORS PRESENCE
(ALUNA, 2021-10) Kopchak Oksana; Odintsova Tetiana; Pulyk Oleksandr
The aim: To clarify the influence of different risk factors on cognitive impairment (CI) in general and in separate domains and their association with MRI findings in patients with relapsing-remitting (RRMS) and progressive forms of multiple sclerosis (SPMS and PPMS). Materials and methods: One hundred and thirty-seven participants with MS (102 females and 35 males) aged from 22 to 69 years were enrolled into this study. All patients completed the Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A) and undergone MRI. Results: According to MS phenotypes all participants were divided into two groups: patients with RRMS (n= 106) and with progressive phenotypes (n= 31). A significant positive correlation was present between MoCA and BDI scores in all participants (p= 0,0015). Presence of anxiety did not demonstrate any valid influence on cognitive performance, although severe anxiety was significantly more often found in subjects with progressive phenotypes in presence of brain atrophy (p= 0,0028). Patients with higher education had no CI more frequently compare to those without it (p= 0,0019), whereas, participants smoking cigarettes had higher prevalence of severe CI than non-smokers (p= 0,0061). Conclusions: Among cognitive domains memory, visual-spatial and executive functions, abstract thinking were impaired the most in MS patients, though abstract thinking was more often affected in progressive forms. The results demonstrated that physical disability, depression and smoking negatively impacted cognitive performance, meanwhile presence of higher education demonstrated a favorable influence on cognition in MS patients.
Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings
(Springer Nature, 2021-09-08) Kopchak Oksana; Odintsova Tetiana
Background: Multiple sclerosis is an insidious, disabling, both physically and mentally, demyelinating disease of the central nervous system. This work aims to evaluate relationships between cognitive impairment in separate domains, depression and their correspondence with MRI-fndings, as well as the infuence on each other’s manifestations, in patients with relapsing–remitting multiple sclerosis. Results: Visual–spatial/executive functions and memory domains sufered more frequently than others in the study subjects under 40 years; in patients over 40 years old memory, visual–spatial/executive functions and abstract thinking impairment prevailed the most. Such cognitive domains as memory, language, abstract thinking, visual–spatial and executive functions were impacted in both groups of patients even without the apparent cognitive decline according to MoCA scale. Presence of depression impacted language and attention more prominently than the rest of the domains only in participants younger 40 years. According to the MRI, frontal lobe, corpus callosum and periventricular area were afected more often compared to other brain regions in case of cognitive impairment; meanwhile, combined lesions of frontal lobe and corpus callosum, fronto-temporal region were associated with depression. Conclusion: Cognitive impairment and depression are one of the common, yet disabling and socially disrupting manifestations of MS. Quite frequently such complaints are neglected or considered as parts of comorbidities. At the same time cognitive impairment can be amplifed by depression, especially in patients under 40 years.
Predicting cognitive impairment and psycho-emotional disorders in Multiple Sclerosis patients according to MRI findings
(AMPH, 2022-12-30) Odintsova Tetiana; Kopchak Oksana
Objectives. The aim of our study was to assess the probability of cognitive impairment (CI) in general and in separate domains, depression, anxiety and sleep disorders onset depending on their association with MRI findings in patients with multiple sclerosis (MS). Materials and methods. 137 patients with MS were enrolled into the study. All participants were divided into two groups: group A included study subjects with relapsing remitting multiple sclerosis (RRMS) and B consisted of patients with secondary progressive multiple sclerosis (SPMS). Results. Participants with progressive forms of MS had a higher risk of CI development compare to the patients with RRMS (p=0,0361). Memory decline onset depended on the presence of the brain atrophy in combination with lesions of the parietal lobe (OR=2.74 (0.85-8.77), p <0.0001) in RRMS cases, furthermore, on presence of combined demyelination in temporal lobe with corpus callosum (OR=17.33 (2.92-103.02), p=0.0006) and parietal lobe separately (OR=7.5 (1.14-49.26), p=0.0239) in patients with SPMS. Conclusions. CI and psycho-emotional disorders can be predicted by means of MRI findings and potentially prevented.
Pros and cons of remote medical education in Ukraine in terms of COVID-19 pandemics
(Elsevier Ltd., 2022-08-24) Kopchak Oksana; Odintsova Tetiana; Bachinskaya Nataliya; Ivniev Borys; Pokanevych Oleksandr
Introduction: COVID-19 is an ongoing pandemic, which forced countries across the globe to adapt all daily activities to the new reality in order to stop the disease from spreading. The educational process was not an exception, it caused a sudden shift towards the exceptional introduction of online teaching and Kyiv Medical University was one of the first universities in Ukraine to assess the quality of education under the restrictive measures Objectives: The aim was to analyze the advantages and disadvantages of online education during the COVID-19 pandemic in the learning of neurology at the Department of Neurology, Psychiatry and Physical Rehabilitation, Kyiv Medical University. Methods: 169 students were interviewed using an online questionnaire consisting of 18 items focused on different angles of educational process. Results: According to the obtained results, the biggest pros of online teaching included: flexibility of learning schedule, learning at your own pace; ability to develop deeper problem-solving and clinical thinking skills. Social distancing, family distractions, and internet connection issues negatively affected most students’ feelings during online learning. One of the most prominent cons of online learning of neurology pointed out by the majority of medical students was a lack of practical component of training and contact with patients. Conclusions: Online teaching, along with a number of advantages, has significant disadvantages, especially in medical education in case of studying clinical disciplines
Psychological well-being of Ukrainian students three months after the emerge of full-scale war
(Polish Psychiatric Association Editorial/Publishing Commitee, 2024) Pinchuk Irina; Solonskyi Andrii; Yachnik Yuliia; Kopchak Oksana; Klasa Katarzyna; Sobański Jerzy; Odintsova Tetiana
Aim. To depict overall psychological well-being of a large group of students of different universities in Ukraine three months after the emerge of the full-scale war. Material and methods. A total of 1,142 participants were asked to measure their psychological well-being on a 0–10 scale before and after the onset of full-scale war. Mental health symptoms were measured with questionnaires targeting depression (PHQ-9), anxiety (GAD-7), sleep problems (ISI), eating disorders (SCOFF), alcohol abuse (CAGE), and PTSD symptoms (PC-PTSD-5). To evaluate the connection between variables a χ2 was conducted. Phi and Cramer’s V coefficient were stated to demonstrate the power of the relationships. Additionally, machine learning (the XGBoost regression model) was used to build a predictive model for depressive symptoms. Results. Of all respondents, 66% screened positive for PTSD symptoms, 45% – moderate and severe anxiety symptoms, 47% – moderate and severe depressive symptoms. Regarding sleep, alcohol use and eating behavior, 19% of surveyed students had signs of moderate and severe insomnia, 15% reported alcohol abuse and 31% disordered eating. The severity of the aforementioned disorders varied depending on gender, year of study, social status, etc. According to the predictive model, lower initial psychological well-being, female gender, younger age, first years of study and any traumatic experience, including multiple trauma, predicted increases in depression score. Return to home after relocation was a protective factor. Conclusions. The study demonstrated the high prevalence of mental health symptoms among university students in Ukraine during the first months of the full-scale war. The psychological well-being pre-war was the strongest predictor of depressive symptoms in the model.
SLEEP DISORDERS IN RELAPSING-REMITTING MULTIPLE SCLEROSIS PATIENTS
(Aluna Publishing, 2021) Kopchak Oksana; Odintsova Tetiana
The aim: Our study aimed at evaluating the relationships between sleep disorders (SD), cognitive impairment (CI), anxiety and depression in patients with relapsing-remitting multiple sclerosis (RRMS). Materials and methods: One hundred and five patients with RRMS (80 females and 25 males) aged from 22 to 67 years (mean age: 41,8±10,7; EDSS:3,5±1,6; disease duration (DD): 10,3±8,5 years) were enrolled into the study. All participants completed questionnaires on sleep (the Pittsburgh Sleep Quality Index /PSQI), cognitive functions (The Montreal Cognitive Assessment /MoCA), anxiety (Hamilton Anxiety Rating Scale /HAM-A), depression (Beck Depression Inventory/ BDI). Results: According to PSQI score the patients were divided into two groups: with (n=42) and without SD (n=63). The patients with SD were older (45,36±1,66 vs 39,41±1,27, p=0.005), had higher EDSS score (3,98±0,26 vs 3,14±0,19, p=0,008), BDI (13,79±1,14 vs 8,96±0,86, p=0,0009) and HAM-A (24,52±1,42 vs 16,56±0,99, p<0,0001) scales compared with patients without SD. The frequency of anxiety (p=0,0034) and depression (p=0,038) was significantly higher in RRMS patients with compared to those without SD. No significant difference was found in gender, DD and MoCA score. In patients with SD significant negative correlation between MoCA and BDI score (r = -0,42, p<0,005) was found. In the group of patients without SD significant negative correlation between MoCA and EDSS (r = -0,27, p=0,03), MoCA and BDI (r = -0,26, p=0,043),) MoCA and HAM-A (r = -0,25, p=0,041) score was detected. Conclusions: Insomnia type SD in RRMS patients were associated with older age, higher EDSS score and presence of anxiety and depression.
Лікування порушень сну, що асоційовані з тривогою, у пацієнтів з розсіяним склерозом
(Харківський національний університет імені В. Н. Каразіна, 2020-06-23) Odintsova Tetiana; Kopchak Oksana; Kobys Tetiana
Порушення сну (ПС) відіграють значну роль у поглибленні інвалідизації та зниженні якості життя пацієнтів з розсіяним склерозом (РС) поряд з моторними, когнітивними та психоемоційними розладами. Метою нашого дослідження було визначення ефективності терапії порушень сну, асоційованих з тривогою, у хворих на РС та оцінка можливого впливу препарату на вираженість втоми, когнітивних розладів та проявів астенії у обстежених пацієнтів. У дослідженні прийняли участь пацієнти з РС ремітуючо-рецидивуючим та вторинно-прогресуючим типами перебігу (середній вік 43,7 ± 8,9 років; тривалість захворювання 11,3 ± 7,6 років), що мали порушення сну різного ступеня тяжкості, асоці-йованих з тривогою. Для дослідження були використані наступні шкали: Піттсбурзький опитувальник на визначення індексу якості сну (PSQI), шкала тривоги Гамільтона (HAM-A), Монреальська шкала оцінки когнітивного статусу (MоCA), модифікована шкала впливу втоми (MFIS) та шкала астенічного стану (ШАС). Відповідно до результатів Піттсбурзького опитувальника якості сну, легкі порушення виявлено до лікування у 10% пацієнтів, помірні – у 35%, тяжкі – у 55% хво-рих. За даними шкали Гамільтона, легку тривожність спостерігали у 30% пацієнтів, помірну – у 25%, тяжку – у 45% па-цієнтів до лікування. З метою лікування було застосовано препарат Валео-Дорм Дуо (кризин, мелатонін). Оцінювались динаміка показників якості сну, тривоги, когнітивних розладів, втоми та астенії із використанням відповідних шкал на тлі лікування. У 70% пацієнтів було виявлено достовірне покращення якості сну у вигляді зменшення частоти ви-ражених розладів сну та зниження рівня тривожності до легкого ступеню у 45% та помірного у 55% згідно результатів шкали тривожності Гамільтона. Застосування препарату Валео-Дорм Дуо виявилося ефективним у лікуванні пацієнтів з РС за умови поєднання порушення сну та тривоги, сприяло нормалізації сну та зменшенню проявів тривоги та астенії, а відтак покращувало якість життя хворих.