Browsing by Author "Yena, M.S., Kuznietsova, H.M., Rybalchenko, V.K."

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    Pyrrole derivatives' effect on rats' colon mucosa in experimental colitis
    (Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2015) Yena, M.S., Kuznietsova, H.M., Rybalchenko, V.K.
    We've studied individual and joint effect of pyrrole derived cytotoxic drugs i.e.1-(4-Cl-benzyl)-3-Cl-4- (CF3-phenylamino)-1H-pyrrol-2,5-dione (MI-1) and 5-amino-4-(1,3-benzothyazol-2-yl)-1-(3-methoxyphenyl)- 1,2-dihydro-3H-pyrrol-3-one (D1) on the morpho-functional state of colon mucosa in rats with experimental colitis. It was found that M1 was more effective and less toxic to mucosa as compared to D1 and a combination of D1and MI-1.