Renal cell carcinomas with tubulopapillary architecture and oncocytic cells: Molecular analysis of 39 difficult tumors to classify.

dc.contributor.authorSlisarenko, Maryna
dc.contributor.authorPivovarcikova, Kristyna
dc.contributor.authorGrossmann, Petr
dc.contributor.authorHajkova, Veronika
dc.date.accessioned2024-12-23T12:21:52Z
dc.date.available2024-12-23T12:21:52Z
dc.date.issued2021-06
dc.description.abstractSo-called oncocytic papillary renal cell carcinoma (OPRCC) is a poorly defined variant of papillary renal cell carcinoma. Since its first description, several studies were published with conflicting results, and thus precise definition is lacking. A cohort of 39 PRCCs composed of oncocytic cells were analyzed. Cases were divided into 3 groups based on copy number variation (CNV) pattern. The first group consisted of 23 cases with CNV equal to renal oncocytoma. The second group consisted of 7 cases with polysomy of chromosomes 7 and 17 and the last group of 9 cases included those with variable CNV. Epidemiologic, morphologic and immunohistochemical features varied among the groups. There were not any particular histomorphologic features correlating with any of the genetic subgroups. Further, a combination of morphologic, immunohistochemical, and molecular-genetic features did not allow to precisely predict biologic behavior. Owing to variable CNV pattern in OPRCC, strict adherence to morphology and immunohistochemical profile is recommended, particularly in limited samples (i.e., core biopsy). Applying CNV pattern as a part of a diagnostic algorithm can be potentially misleading. OPRCC is a highly variable group of tumors, which might be misdiagnosed as renal oncocytoma. Using the term OPRCC as a distinct diagnostic entity is, thanks to its high heterogeneity, questionable.
dc.identifier.citationPivovarcikova K, Grossmann P, Hajkova V, Alaghehbandan R, Pitra T, Perez Montiel D, Sperga M, Rogala J, Slisarenko M, Bartos Vesela A, Svajdler P, Michalova K, Rotterova P, Hora M, Michal M, Hes O. Renal cell carcinomas with tubulopapillary architecture and oncocytic cells: Molecular analysis of 39 difficult tumors to classify. Ann Diagn Pathol. 2021 Jun;52:151734. doi: 10.1016/j.anndiagpath.2021.151734. Epub 2021 Mar 31. PMID: 33838490.
dc.identifier.doi10.1016/j.anndiagpath.2021.151734
dc.identifier.urihttps://ir.kmu.edu.ua/handle/123456789/681
dc.language.isoen_US
dc.publisherAnnals of Diagnostic Pathology
dc.subjectCopy number variation pattern
dc.subjectKidney
dc.subjectOncocytic renal cell carcinoma
dc.subjectOncocytoma
dc.subjectOverlapping
dc.subjectPapillary
dc.subjectUnclassified
dc.titleRenal cell carcinomas with tubulopapillary architecture and oncocytic cells: Molecular analysis of 39 difficult tumors to classify.
dc.typeArticle

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Renal_cell_carcinomas_with_tubulopapillary_architecture_and_oncocytic_cells_Molecular_analysis_of_39_difficult_tumors_to_classify.pdf
Size:
127.83 KB
Format:
Adobe Portable Document Format

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description: