Факультет фармації та психології

Permanent URI for this communityhttps://ir.kmu.edu.ua/handle/123456789/78

Browse

Now showing 1 - 20 of 121

A Review of the Novel Antidiabetic Medications: Efficacy, Safety and Innovation
(Bentham Science Publishers, 2023-04-14) Sepideh Parchami Ghazaee; Viktor Tumanov; Natalia Voloshyna; Kateryna Marchenko-Tolsta; Murtaza Hameed
ntroduction: Type 2 diabetes is a chronic health condition affecting hundreds of millions of people. Type 2 diabetes has traditionally been combated with a combination of lifestyle modification, insulin therapy and pharmacological agents, including sulfonylureas, biguanides, thiazolidinediones and alpha-glucosidase inhibitors. Type 2 diabetes is associated with an increased risk of cardiovascular disease and the development of diabetic kidney disease. Although sulfonylureas are low-cost drugs and widely prescribed, they have been shown in recent cardiovascular outcome trials to present a high risk of hypoglycemia, which in turn increases the risk of negative cardiovascular outcomes. Metformin, a biguanide that is the most commonly-prescribed antidiabetic agent worldwide, is contraindicated in patients with risk factors for lactic acidosis, including heart failure and chronic kidney disease. Objectives: The last decade has seen significant advances in the development of novel antidiabetic agents shown to possess both reno- and cardioprotective qualities. This article aims to review the available literature and recent studies demonstrating the efficacy and safety of these agents individually, as well as exploring areas of future development in the field. Methods: The reporting of this review is based on the 2020 PRISMA statement. A literature search for all papers related to antidiabetic medication was conducted using reliable sources such PubMed and Google Scholar Databases, including a recent meta-analysis of renal and cardiovascular outcome trials. Conclusion: A critical analysis of clinical trials on type 2 diabetes and the two most severe comorbidities in cardiovascular and chronic kidney diseases may help cardiologists, urologists and diabetes specialists to adapt their therapeutic approaches to individual patients. Data related to antidiabetic effects of agents of natural origin accompanied by their Cardioprotective and renoprotective capacity testify benefits of these compounds as novel therapeutic agents.
A Systematic Review of the Novel Targeted Immunobiological Medications in Rheumatoid Arthritis: Efficacy, Safety, and Innovation
(Bentham Science Publishers, 2024-03-28) Sepideh Parchami Ghazaee; Kateryna Marchenko-Tolsta; Petro Sereda; Murtaza Hameed; Sandra Lane
Introduction: Over the last half-century, the treatment and management of autoimmune rheumatic diseases have progressively improved, particularly with the contribution of immunobiological or biological therapies known as disease-modifying antirheumatic drugs. Although these agents have been generally efficient in the management of rheumatoid arthritis (RA), some patients experience limited efficacy and non-responsiveness to treatment. In addition, they may cause adverse clinical effects, further aggravating the disease. Objectives: Despite advancements in biological therapies, significant clinical needs persist. This review aims to discuss novel treatments, guiding future guidelines and drug discoveries for rheumatoid arthritis. Methods: This review follows the 2020 PRISMA statement, utilising PubMed and Google Scholar for literature search and emphasizing recent meta-analyses on the safety and efficacy of targeted immunobiological medications. Results: Small molecule inhibitors, whether utilised independently or in conjunction with Methotrexate, have been shown to contribute to effective disease management and have the potential for better adherence to the American College of Rheumatology criteria. Tocilizumab therapy demonstrates a significant reduction in disease activity and improves rates of disease remission when combined with Methotrexate. Investigations of mesenchymal stromal cell therapies have had promising outcomes, improving both cartilage quality (as evaluated by Macroscopic Cartilage Repair Assessment) and joint tenderness and swelling in clinical joint counts. Intra-articular administration of tolerogenic dendritic cells has displayed a capacity to alleviate pain, as measured by Visual Analog Scale scores, and enhance the Disease Activity Score across 28 joints. Resveratrol capsules supplemented with allopathic therapy show potential in reducing TNF-α and interleukin-6 serum levels. Conclusion: More investigations and their analysis will improve patient outcomes and reduce adverse effects and the costs involved in developing and obtaining immunobiological drugs. Moreover, assessing the safety and efficacy of anti-RA properties of the bioactive compounds could offer less toxic and more cost-effective natural treatment options.
ANALYSIS OF THE APPLICATION OF ANTIBACTERIAL PREPARATIONS BY STUDENTS OF THE MEDICAL UNIVERSITY
(Sole proprietorship -Gulyaeva V.М., 2021-03-27) Parchami Ghazaee Sepideh; Nikolaievska Yelyzaveta; Hryshkov Mykola; Tumanov Viktor
ANTI-INFLAMMATORY PROPERTIES OF PHYTOCONSTITUENTS IN MANAGING RHEUMATOID ARTHRITIS
(LLC UKRLOGOS Group, 2024-05-12) Parchami Ghazaee Sepideh; Marchenko-TolstaKateryna; Novykova Larisa; Hryshkov Mykola
Combining phytochemicals with conventional therapy may create a synergistic, anti-inflammatory and anti-arthritic effect in treating rheumatoid arthritis (RA), while potentially mitigating the associated toxicity
Antimicrobial properties of a new polymeric material based on poly(2-hydroxyethyl methacrylate)
(Jornal © Mattioli 1885, Acta Biomed, 2021-09-21) Chornopyshchuk Roman; Nagaichuk Vasyl; Gerashchenko Igor; Nazarchuk Halyna; Kukolevska Olena; Chornopyshchuk Nataliia; Sidorenko Svetlana
Background and aim. Оne of the promising areas is the development of synthetic wound dressings with programmed release of active substances that can affect various elements in the pathogenesis of the wound process. The aim was to study the antimicrobial properties of a new polymeric material based on poly(2-hydroxyethyl methacrylate). Methods: 2-hydroxyethyl methacrylate, dimethacrylate triethylene glycol as crosslinking agent, polymerization initiator of azobisizobutyronitrile along with a porogen and one of the antimicrobial agents, including decamethoxin, chlorhexidine bigluconate, silver nitrate, octenidine, furacilin, metronidazole, dioxidine, and gentamicin were used to synthesize a new material with antimicrobial activity. For comparison, polymer samples synthesized without adding antimicrobials were used, as well as known dressing materials: activated carbon material, porcine skin, which were immersed into 0.02% decamethoxin solution before use, as well as silver-containing dressing, hydrogel dressings, including those filled with silver. Determination of antibacterial properties was performed by diffusion method. Results. Low antimicrobial activity of the studied existing wound dressings, which are widely used in medical practice, even under conditions of their saturation with antiseptic substances, has been established. Samples of the suggested polymeric material with the addition of antimicrobial substances showed the ability to inhibit the growth of the test strains of microorganisms at a sufficient level, especially with such fillers as decamethoxin, gentamicin, dioxidine. When metronidazole was added to the polymeric material, a reliable antimicrobial effect on the anaerobic microorganisms was established. Conclusions. Modification of the polymeric material of poly(2-hydroxyethyl methacrylate) by adding antimicrobial substances allows to ensure its high antimicrobial properties against different microorganisms. (www.actabiomedica.it)
Antimonium crudum in pediatric skin conditions: A classical homeopathic case series
(John Wiley & Sons, Inc, 2020-12-16) Mahesh Seema; Kozymenko Tamara; Kolomiiets Nataliia; Vithoulkas George
Homeopathic Antimonium crudum may be useful in many pediatric skin conditions if prescribed on symptom similarity. It may especially be helpful in reducing the use of antibiotics and steroids in this age-group if proven to be effective through larger scientific studies
APPLICATION OF INNOVATIVE EDUCATIONAL METHODS IN TEACHING MEDICAL AND PHARMACEUTICAL DISCIPLINES
(RS Global Sp. z O.O., Poland, 2024-06-09) Новикова Лариса Георгіївна; Марченко-Толста Катерина Сергіївна; Білан Ольга Анатоліївна
The article examines the peculiarities of the generation of modern students and teachers involved in the educational process from the point of view of generational theory and modern ideas about general and professional competencies in medical/pharmaceutical higher education. Innovative approaches and methods, and modern educational technologies used in teaching medical and pharmaceutical disciplines are summarised, and the prospects for transition to a new design of the educational space are analyzed.
APPLICATION OF PHARMACOGENOMICS IN STATIN THERAPY
(P.C. Publishing House & UKRLOGOS Group LLC, 2024-08-16) Zakrutko Lesya; Kozymenko Tamara; Zolotaikina Marharyta; Fedorytenko Roman
AREVIEWOFTHEANTICANCERNATURALPRODUCTS:ALKALOIDS,FLAVONOIDS
(ДрукарняФОПГуляєваВ.М., 2022-09-05) Ghazaee Parchami; Kateryna Marchenko-Tolsta
According to the international agency for research on cancer 1 in 5 people develop cancer during their lifetime, suggesting that more than 50 million people are living within five years of a past cancer diagnosis (World Health Organization (WHO, 2020, para. 1). Despite novel approaches like nanomedicine, targeted therapy, and immunotherapy in cancer treatments during the last decades, chemoresistance has remained the chief hurdle in eliminating cancerous cells (Elgendy , Alyammahi & Alhamad, 2020, p. 103095). About 9 out of 10 cancer deaths are due to spreading of cancer cells from the primary tumor mass towards close and far tissues (a process called metastasis). Treatment failure followed by consequent recurrence of cancer cells and metastasis is the leading cause of death. Many survivors suffer from serious acute or chronic complications after cancer therapy (Qian, Mei, & Zhang, 2017, p.38). Furthermore, chemotherapy commonly induces a variety of side-effects in patients as a result of nonspecific action against both normal cells and cancerous cells. For instance, chemotherapeutic drugs result in alopecia by affecting not only fast dividing cancer cells, but hair follicles as well. Nausea and vomiting are the most common symptoms induced by chemotherapy, with gastrointestinal symptoms including diarrhea (and in some cases constipation) being another common side effect. Chemotherapy is also known to impair immune function and bone marrow activity (Li et al., 2020, p.599073). The identification of approved doses of anticancer drugs is another point to be given careful attention, especially those with higher cost and administered for a longer duration. Larger doses of chemotherapeutic drugs may increase the risk and severity of the aforementioned side effects, and are not cost-saving. Therefore, phytomedicines should be considered as an option not only for adjuvant therapy, but also in view of their comparatively low toxicity and ability to diminish adverse effects of chemotherapy in cancer patients. Natural products and their derivatives can be used as novel therapeutic interventions with improved pharmacological properties targeting tumor cells (Meriggi & Zaniboni, 2020, pp.1–11).
BIOLOGICAL ACTIVE SUBSTANCES OF NATURAL ORIGIN AND RHEUMATOID ARTHRITIS, PREVENTION OR TREATMENT?
(ФОП Гуляєва В.М., 2023-05-23) Ghazaee Parchami; Kateryna Marchenko-Tolsta
According to population-based studies, the global prevalence of RA between 1980 and 2019 was 460 per 100,000 population. Trend analysis showed that RA was observed more in developed countries than developing countries (Almutairi, 2020, pp. 863-877). Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the symptomatic treatment options for RA. However, these medications are known to have multiple adverse effects including nephrotoxicity, gastrointestinal bleeding and ulceration, increasing blood pressure and the risk of first hospitalization due to congestive heart failure. Conventional disease modifying anti-rheumatic drugs (DMARDs) are usually the first choice to diminish disability and improve long-term outcomes for people with RA. Biologics are much more costly than other subsets of DMARDs, they are commonly used as partial responders to traditional DMARDs. Although the combination of biologics and traditional DMARDs has demonstrated improved efficacy, the potential benefits and harms (such as cancer and infections) are still controversial. However, in spite of applying aggressive pharmacologic treatment regimens early in disease onset, complete clinical remission is not achieved (Guo et al., 2018, p.15). Although biological medications seem to effectively target molecular pathways involved in the inflammatory process of RA, there is a lack of long-term safety data regarding their use. Various investigations have demonstrated an increased prevalence in the use of herbal medicine in developing countries. Interestingly, a rise in the prevalence of herbs used as complementary and alternative medicine among chronic disease patients has been reported in recent years. The anti-inflammatory properties of some herbal products are well-known and they have fewer unwanted effects than existing anti-inflammatory medications. As such, herbs and their derivatives constitute a promising arena in novel medical therapies. Furthermore, the cost-effectiveness of natural products has been explored and summarized by high quality studies. Certain phytochemicals are considered to inhibit the release of inflammatory molecules to suppress inflammatory responses (Gandhi et al., 2022, pp.1-15). is the precursor of ellagitannin and has been reported to be the most active polyphenol obtained from different parts of the pomegranate tree (Punica granatum Linn.). Methanolic (and ethanolic) pomegranate peels extract contains a high amount of bioactive compounds including punicalagin (10-50 mg∕g) ( Xu et al., 2021, pp.1-12). Historically, seeds and juices are believed to have been taken as supplements to reduce the clinical symptoms of RA (Singh, Singh, & Mahajan, 2020, pp. 1306-1327). Marques and coauthors (2016) have already revealed that Punicalagin diminished TNF α and interleukin (IL) 6 secretion in macrophages and primary human chondrocytes with lipopolysaccharide (LPS)-induced inflamed RAW264.7. (Marques et al., 2016, pp- 463-1467). Anthocyanins have been shown to represent potent anti-inflammatory, anti-oxidant, anti-cancer, anti-obesity and immunomodulatory activity. (Salehi et al., 2020, pp.1-20). Min and coauthors (2015) reported inhibitory effect of ACNs on osteoclasts via the downregulation of cytokines including IL-1, IL-6, IL-17, and TNF-α in vitro. the study showed EA reduced cartilage destruction, synovial hyperplasia and bone erosion generated by Freund’s adjuvant. Significant suppression of caspase-3 expression in models treated with EA testifies to the anti-apoptotic property of this biologic compound (Fikry, Gad, & Eid, 2019, pp. 878–886).
CARDIOTROPIC INFLUENCE OF SYNTHETIC AND GENETICALLY-ENGINEERED SUPPRESSORS IN RATS WITH EXPERIMENTAL RHEUMATOID ARTHRITIS COMBINED WITH ARTERIAL HYPERTENSION
(Світ медицини та біології, 2020) Seredynska N.M.; Korniyenko V.I.; Marchenko-Tolsta K.S.; Bobrytska O.M.; Ladohubets O.V.; Duchenko K.A.
Significant progress in rheumatoid arthritis pharmacotherapy is associated with the implementation of synthetic–derived immunosuppressors and genetically engineered (biological) drugs) into clinical practice. Arterial hypertension, like rheumatoid arthritis, is accompanied by producing a large amount of inflammatory cytokines, namely TNF–ά. The purpose of the work was to study the cardiotropic effects of leflunomide and etanercept against the background of experimental rheumatoid arthritis associated with arterial hypertension in rats. Experiments on mature adult, non-linear white rats found that leflunomide and etanercept did not affect the degree of hypertension against the background of adjuvant arthritis, but manifested an antihypertensive effect when used in adjuvant arthritis combined with arterial hypertension. Leflunomide leads to an increase in heart rate by 5–10.4% at different terms of observation, both against the background of adjuvant arthritis only and under the combined pathology conditions. Etanercept, when used against adjuvant arthritis, causes bradycardia but prevents the development of tachycardia, which is detected in untreated animals with a comorbid condition during manifestation and attenuation of the inflammatory process. The study findings may be relevant for development of new approaches to the treatment of rheumatic and cardiac pathology.
COMMUNITIES AND ATTITUDES ON THE USE OF HERBAL REMEDIES IN THE TREATMENT OF COVID-19: A REVIEW
(SCIENTIFIC-DISCUSSION, 2024-07-06) Parchami Ghazaee S.; Marchenko-Tolsta K.; Novykova L.; Hameed M.
The established antiviral properties exhibited by certain medicinal plants, coupled with additional advantages such as minimal adverse effects and cost-effectiveness, have elicited a heightened inclination among the public towards natural therapies for the management of diseases. Amid the COVID-19 pandemic, anecdotal reports from residents across seven countries in Latin America and the Caribbean (LAC) underscore the inclination of healthcare professionals and spiritual leaders to recommend specific medicinal plant interventions. Notably, Zin- giber officinale, Curcuma angustifolia, and Allium sativum emerge as frequently cited species employed by com- munities in Nepal, with Zingiber officinale Rosc., honey (Mel), garlic (Allium sativum L.), and perilla (Perilla frutescens (L.) Britt.) being prevalent herbal remedies in Vietnamese communities, especially for addressing res- piratory symptoms associated with COVID-19. The observed self-administration of these herbal medicines may serve as a catalyst, motivating researchers within the pharmaceutical industry to conduct comprehensive scientific assessments to validate their efficacy, reliability, and optimal dosage.
Comparative analysis of biologically active substances of Ocimum basilicum l. and Ocimum gratissimum L.
(Modern chemistry of medicines: Матеріали Міжнародної Internet-конференції. Електрон. дані. Х. : НФаУ, 2023-05-18) Nnamani J.I.; Kalista M.S.; Konovalova O.Yu.; Hurtovenko I.O.
DEVELOPMENT OF STRESS RESISTANCE OF MEDICAL MULTI- PROFILE WORKERS BY THE PSYCHOSYNTHESIS METHOD
(University of National and World Economy Bulgaria, 2020) Kucherenko Yegor; Rudnieva Kateryna
The problem of the development of stress resistance of medical workers, in our opinion, cannot be solved methodologically within the framework of only professional activity, since the appearance and manifestation of stress is associated with various factors, in particular, personal ones. We proceeded from the fact that pro- fessional stress is a consequence of not only the direct fulfillment of professional duties of varying complexity, but also depends on the holistic experience of personal activity outside of work, and therefore it is advisable to study stress in general. The key novelty of our study was psychosynthesis as a method for the development of stress resistance of doctors of various specializations, which was not previously undertaken to solve this problem within Ukrainian psychology. This publication reviews the results of an empirical pilot study that we conducted in the spring of 2019, as well as the theoretical justi- fications of psychosynthesis as a methodological basis for solving the problems found.
Experimental Substantiation of Antimicrobial Efficiency of a New Composite Polymeric Material Based on Poly(2-Hydroxyethyl Methacrylate) under the Action of Low-Intensity Current without External Power Supplies
(Trans Tech Publications Ltd, Switzerland Online:2021-07-13, 2021-07-13) Nagaichuk, Vasyl; Chornopyshchuk, Roman; Gerashchenko, Igor; Kukolevska, Olena; Sidorenko, Anatolie
Active use of polymeric materials has become an integral part of all areas of modern medicine. Wound dressings capable of prolonged release of drugs directly into the lesion occupy a special place among them. The possibility of using such materials in the presence of low-intensity currents without external power supplies in a comprehensive treatment program for patients with burn injuries remains promising. The aim of the work is to study experimentally the antimicrobial efficacy of a new composite polymeric material based on poly(2-hydroxyethyl methacrylate), saturated with the antiseptic decamethoxine, under conditions of low-intensity current without external power supplies. The method of free radical thermal polymerization of a mixture of liquid monomer 2-hydroxyethyl methacrylate, crosslinking agent triethylene glycol dimethacrylate, polymerization initiator azobisisobutyronitrile was used for the synthesis of composite polymeric material. In addition, fourfold volume of distilled water as a pore-forming agent and decamethoxine as an antimicrobial component were administered. Known dressings of synthetic and biological origin were selected for comparison, some of which were pre-soaked in a 0.02% solution of decamethoxine. The study of conductivity of the materials without external power supplies was performed on the surface of a dense nutrient medium in a Petri dish using VITA-01M measuring device. Determination of antibacterial properties was performed by diffusion into agar. The obtained results allowed to establish the ability of the suggested polymeric material to conduct low-intensity currents without external power supplies, exceeding the duration of other traditional dressings. Comparison of antimicrobial activity of the studied samples confirmed the synergism of the action of physical factors and a new polymer-based composite material with the addition of antimicrobial substance to inhibit the growth of the test museum and clinical strains of Staphylococcus aureus . The ability of low-intensity currents without external power supplies to potentiate the antimicrobial properties of a new composite polymeric material based on poly(2-hydroxyethyl methacrylate), modified with a pore-forming agent, with the addition of decamethoxine was experimentally established.
Exploring Phytotherapy's Preventive and Therapeutic Impact on Global COVID-19 Management: A Narrative Review
(Bentham Science Publishers, 2024-04-22) Sepideh Parchami Ghazaee; Petro Sereda; Kateryna Marchenko-Tolsta; Murtaza Hameed
Introduction: The WHO Emergency Committee advocates preventive strategies for COVID-19 management, emphasising vaccines as highly effective but acknowledging their limitations. Chloroquine and hydroxychloroquine, initially effective against COVID-19, were discontinued due to severe side effects. Further clinical trials are imperative to establish the safety and efficacy of new antiviral agents, some of which may have harmful effects on human development. Objectives: The shortcomings of various conventional treatments have prompted urgent efforts to discover safe, natural compounds that may be useful in combating COVID-19. This study aims to review research that has investigated the potential of traditional phytotherapies used by different populations for the prevention and symptomatic treatment of COVID-19 infection. Methods: This paper reviewed scientific studies published through searching on search engines such as PubMed, Scopus, Google Scholar, ScienceDirect and Elsevier from May until October 2023. Results: The preventive and anti-COVID-19 attributes of Traditional Chinese Medicine, Ayurvedic formulations and African medicinal plants have been substantiated in research. In Nepal, recommendations endorse the utilisation of medicinal plants for herbal teas and homemade sanitizers. Zingiber officinale, Curcuma longa L. and Curcuma xanthorriza Roxb., along with Camellia sinensis are crucial Indonesian medicinal plants with potential for treating COVID-19. Z. officinale was predominantly chosen for relieving coughs and sore throats associated with COVID-19 in Saudi Arabia. Discussion: The immunomodulatory properties of medicinal plants, which may prove useful in combating COVID-19, have been verified via elevation of the level of peripheral WBCs, IgM, IgG; inhibition of leukotrienes and prostaglandins, maintenance of the integrity of intestinal mucosal barrier and regulation of HMGB1. The antiviral effects of herbs, including the inhibition of viral DNA and RNA replication, down-regulation of oxidative stress, and the impediment of SARS-CoV-2 access to vascular endothelial cells, suggest their potential to facilitate earlier recovery from COVID-19 infection. Conclusion: Advancing scientific research in phytotherapy promises the possibility of novel approaches for effectively managing future infectious diseases and pandemics.
Identification of the main compounds of Agastache Foeniculum essential oil by TLC and chemotype express-determination
(Журнал Фітотерапія. Часопис. Науково-практичне фахове видання, 2023-02-17) KONOVALOVA Olena; HURTOVENKO Iryna; SHURAEVA Tamara
Topicality. Agastache foeniculum essential oil has bactericidal, fungicidal and anti-inflammatory effects. Depending on the dominant component of the essential oil, five Agastache chemotypes have been distinguished. So, identification of the main compounds of Agastache foeniculum essential oil in other to find markers for the chemotype determination and standardization of raw materials is advisable. The purpose of the research was to study the possibility of identifying the main terpenoids in the Agastache foeniculum raw materials by the method of “cold” thin layer chromatography (TLC) for the chemotype determination. Materials and methods. The TLC was used for investigation with ethyl acetate – toluene (1:19) as mobile phase and special conditions: a temperature of elution +15o C and drying of chromatographic plates in a stream of cool air. Research results. Menthol, linalool and pulegone by the method of “cold” TLC, in the Agastache foeniculum raw material grown in Kyiv were identified. The predominance of pulegone allows us to attribute the raw materials to pulegone chemotype. Estragole and limonene were identified in the Agastache foeniculum raw material grown in Kherson region with a predominance of estragole that allows us to attribute this raw material to the estragole chemotype. Conclusions. The technique above of terpenoids identification ensures the specificity of the determination of the main components of Agastache foeniculum essential oil for the chemotype determination and its standardization.
IMPACT OF PHARMACOGENOMICS ON PHARMACOKINETIC OF BETA BLOCKERS
(P.C. Publishing House», United Kingdom, 2024-07-29) Zolotaikina Marharyta; Fedorytenko Roman; Kurmanska Larysa; Kirkilevska Liudmila
Beta adrenergic blockers (β‐blockers) antagonize beta-1, beta-2 adrenergic receptors, and have been widely used for cardiovascular therapy, as well as treatment of disorders such as anxiety, thyrotoxicosis and glaucoma.
Investigation of the polyphenol composition of red oak (Quercus rubra L.) raw materials
(Journal ScienceRise: Pharmaceutical Science, 2023-04-30) Konovalova Olena; Omelkovets Tetiana; Hurtovenko Iryna; Sydora Natalia; Kalista Mariia; Shcherbakova Olha
The aim of the work was to determine the main groups of polyphenolic compounds in Quercus rubra L. raw materials. Materials and methods. The leaves and annual shoots of Northern Red Oak used for research were collected in August in Lisnyky village of Obuhiv district of Kyiv Oblast (Ukraine). Determination of the component composition and quantitative content of flavonoids (including separately catechins), hydroxycinnamic acids, and phenolic acids were carried out in the samples of air-shade-dried crushed raw material to a particle size of 3 mm by the method of high-performance liquid chromatography (HPLC). Agilent Technologies 1200 liquid chromatograph was used for liquid chromatography. Results. Using the HPLC method, 18 polyphenolic compounds were identified in leaves and annual shoots of Northern Red Oak, in particular, flavonoids: rutin, quercetin-3-β-glucoside, luteolin, neohesperidin; catechins: catechin, epicatechin, epicatechin gallate, gallocatechin; hydroxycinnamic acids: chlorogenic, caffeic, trans-ferulic, trans-cinnamic, p-coumaric, hydroxyphenylacetic, benzoic, syringic, sinapic acids; phenolic acid is gallic acid. The dominant component among flavonoids is rutin (323.43 mg/100 g) (in the composition of catechins, epicatechin gallate (25.45 mg/100 g) prevails); among hydroxycinnamic acids in Northern Red Oak raw materials, chlorogenic acid (139.62 mg/100 g) and sinapic acid (74.64 mg/100 g) prevail. Conclusions. The obtained results point to the prospects of further phytochemical and pharmacological studies of Quercus rubra raw materials, with the aim of creating new plant substances based on it with antioxidant, anti-inflammatory, and antiviral activity
METHODS TO MOTIVATE REMOTE TEACHERS IN A PANDEMIC ENVIRONMENT
(RS Global Sp. z OO, 2021-04-17) Лозова Олена Василівна; Білан Ольга Анатоліївна; Новикова Лариса Георгіївна; Марченко-Толста Катерина Сергіївна
The article examines the factors that affect the success of university remote teachers in a pandemic environment, the importance of maintaining the work motivation of teachers to ensure high performance e-learning, and the need for joint efforts by teachers and university administration to prevent professional burnout and maintain a sense of belonging to the team

Browse

Browsing Факультет фармації та психології by Title