Факультет безперервного професійного медичного розвитку
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Item CANCER-ASSOCIATED ADIPOCYTES AND PROGNOSTIC VALUE OF PREOPERATIVE NEUTROPHIL-LYMPHOCYTE RATIO IN GASTRIC CANCER(Experimental Oncology, 2023) Bubnovskaya, L.; Osinsky, D.; Merentsev, S.; Ganusevich, I.Item Characteristics of pathological types of breathing in children with community-acquired pneumonia using the "TrembitaCorona" acoustic monitoring device(2024-05-24) Khomych Olha; Malezhyk Oksana; Popova Liudmyla; Kyzyma Natalia; Marushko YuriyCharacteristics of pathological types of breathing in children with community-acquired pneumonia using the "Trembita- Corona" acoustic monitoring deviceItem Clinical characteristics of patients with disorders of carbohydrate metabolism in combination with cardiovascular pathology against COVID-19(2022) Taktashov H. S.; Voloshyn Ya. V.; Hrona N. V.The presence of comorbid diseases of the cardiovascular and endocrine systems determines the severity of the course, features of treatment and prognosis in patients with COVID-19. The study of the features of clinical parameters of this combined pathology will allow to improve the approaches to the strategy and tactics of such patients’ management.Item Clinical, Laboratory, Instrumental, Anamnestic Characteristics in Children With Type I Diabetes Mellitus and Early Stage of Diabetic Nephropathy(Global Pediatric Health, 2021-11-10) Shevchenko Tetiana A.; Burlaka Ievgeniia A.; Mityuryayeva Inga O.; Holoborodko Anastasiia D.; Kovalchuk Ihor V.; Lantukh Lilia O.Type 1 diabetes (T1D) is mainly a disease of children and young adults. Diabetic nephropathy (DN) is a common finding in diabetic patients. Microalbuminuria is the earliest clinical evidence of DN. Aim of the study was analysis of clinical, laboratory, instrumental, anamnestic examinations data in pediatric patients with T1D and early stage of DN in order to evaluate possible factors associated with early stage of DN and predictors of DN development and progression. A survey of 105 children (62 males, 43 females) with T1D and DN aged 5 to 17 years in Endocrinology unit on Clinical Pediatric Hospital №6 (Kyiv, Ukraine) done. Following clinical and biochemical characteristics found associated with an early DN: inflammatory phenotype (increased ESR, decreased albumin/globulin ratio), functional cardiovascular disorders (increased systolic blood pressure, “minor” ECG changes), signs of secondary metabolic disorders (high HbA1c, increased serum cholesterol level, increase ALAT and ASAT levels). Kidney function impairment at early stage of DN shows: higher MAU grade, GFR decline, rise in serum creatinine level as compared to T1D group. Presence of concomitant kidney and endocrine disease; positive family history found in a bigger number of patients with DN. DKA episodes number found as a factor associated with higher levels of MAU in children with DN. Patients who had microalbuminuria and more than 5 episodes of DKA/year (poorly controlled T1D) have higher progression rate to macroalbuminuria as compared to those who have less than 5 episodes of DKA/year after a 6-year follow-up study.Item Concept review of ehealth development in Ukraine at the current stage(2021) Taktashov H. S.; Petriaeva O. B.; Hrona N. V.; Voloshyn Ya. V.; Suprun O. O.The concept of eHealth in Ukraine is based on the formation of a roadmap for the development of the system taking into consideration the current status, existing and possible problems. The ways to positive reform achievement are in the area of improving and quality implementation of regulatory and legal framework, resource, organizational, management and technical support along with the implementation of security and availability of e-health.Item Effect of Long-term Peripheral Nerve Stimulation on Neuro- Muscular Complex Morphologic Recovery in Experiment(J. Morphol.,, 2024) PETRIV, T; ALMHAIRAT, R.; LIKHODIEVSKIY, V.; LUZAN, B.; TSYMBALIUK, Y.; VASLOVYCH, V.; MALYSHEVA, T.; TSYMBALIUK, VItem Efficiency and Safety of Umbilical Cord Mesenchymal Stromal/ Stem Cells in Multiple Sclerosis Combined Treatment(J. Morphol, 2022) PETRIV, T.; TATARCHUK, M.; RYBACHUK, O.;; TSYMBALIYK, Y.; TSYMBALIUK, V.Item FUNCTIONAL AND STRUCTURAL EFFECTS OF VITAMIN D ON DIABETIC KIDNEY(INTERNATIONAL JOURNAL OF CURRENT RESEARCH, 2021-01-30) Shevchenko T.A.; Burlaka Ie. A.Vitamin D is vitamin and hormone with huge range of calcium-dependent and calcium-non- dependent functions. Chronic kidney disease and diabetic nephropathy patients have a high incidence of cardiovascular and infectious morbidities. Increasing evidence indicates a relationship between vitamin D deficiency and cardiovascular and infectious mortality risks. Kidne is a target organ for Vitamin D3. This article is to review and summarize the pleiotropic effects of Vitamin D in patients with Diabetes Mellitus and Diabethic Nephropathy.Item General Care of a Patient (Manual Part 1)(Київський медичний університет УАНМ, 2017) Batushkin V.V.; Mozhdehi Z.K.Методичні вказівки з догляду за хворими для студентів 2 курсу медичного факультету англомовної форми навчання.Item Hepatobiliary System Lesions in Children with COVID-19. Literature Review and Own Observations(ECronicon, 2022-06-30) Sergiy Kramarov; Iryna Seriakova; Vitalii Yevtushenko; Liudmyla Palatna; Iryna Shpak; Valerii Shadrin; Nataliia Kyrytsia; Mariia Dudnikova; Hanna Zaslavska; Inna GrynevychBackground: The relevance of this topic is due to the increasing incidence of hepatobiliary system in patients infected with SARS-CoV-2. COVID-19-associated hepatitis occurs in 15 - 65% of adult patients and 6 - 27% of children. Aim: To determine the association of hepatobiliary disorders with different variants of SARS-CoV-2 in children with coronavirus infection (COVID-19) who underwent inpatient treatment during a pandemic. Materials and Methods: 945 case histories of children from birth to 17 years of age, who were hospitalized in KCCCIDH in Kyiv, Ukraine with a diagnosis of coronavirus disease in the period from June 2020 to February 2022, were retrospectively studied. Among them were selected cases with elevated bilirubin, ALT and AST. The peculiarities of the results of instrumental and laboratory researches were determined. A distinction was made by age and periods of the pandemic. Statistical software EZR v. 1,54 was used to conduct a statistical study of the obtained results, using the methods of descriptive statistics. Results: An increase in ALT was observed in 8.4% (72/854) cases, an increase in AST in 19% (162/854) patients and an increase in total bilirubin in 3,6% (31/854) patients. In the age structure there was a predominance of all indicators in groups of children from birth to 1 year and age category 1 - 5 years. According to ultrasound, hepatomegaly was registered in 165 (17,5%) with a predominance in children 1 - 5 years, which accounted for 57 (6%) cases. There was a statistically significant increase in ALT and AST during the fourth wave compared to previous outbreaks, p < 0,001. Conclusion: The dependence of transaminase changes on the COVID-19 period in children was revealed. Liver damage may be related to SARS-CoV-2 virus. However, there is still a need for further research to study this relationship in detail and to understand the pathogenetic mechanisms of hepatitis in coronavirus infection in children.Item Integrated and innovative approach to the study of the subject «CARDIOLOGY» at higher medical institutions(2020) Hrona N. V.; Suprun O. O.The active development of cardiology specified by the introduction of non-invasive and invasive informative diagnostic methods and numerous recommendations for treatment and prevention of cardiovascular diseases requires the training of a highly organized cardiologist. The purpose of this process is to educate a student who both has classical clinical analytical thinking and is well oriented in a great amount of information of modern laboratory and instrumental methods of examination and treatmentItem Methodical aspects of interactive students learning in medical HEI (higher educational institution) in studying in the subject «Internal medicine»(2020) Taktashov H. S.; Hrona N. V.The use of interactive forms of learning develops such important competencies as knowledge, skills, ability, desire for self-development in the learner. Interactive methods are best suited for a personality-centered approach since they involve co-teaching (collective, co-operative learning) with both the student and the teacher who are the subjects of the learning process. Thus, the use of interactive teaching methods increases the level of motivation in the development of the skills of general vocational training and the study of modern scientific achievements.Item MODIFIED TECHNIQUE OF PENETRATING KERATOPLASTY IN COMPLICATED CASES(2023) Veselovskaya, Zoya; Veselovskaya, Nаtalia; Pyatiizbyantceva, Olga; Zaporozchenko, InnaItem Neuron-specific enolase level research in children with COVID-19(Bangladesh Journal of Medical Science, 2024-04) Seriakova Iryna; Kramarov Sergiy; Yevtushenko Vitalii; Kyrytsia Nataliia; Shadrin Valerii; Voronov Oleksandr; Byk Vitalii; Grynevych Inna; Zaslavska Hanna; Zlobynets AntoninaIntroduction COVID-19 is a relevant issue for scientists around the world. Considering the development of numerous complications due to COVID-19, the search for diagnostic approaches for the timely detection of probable lesions of the nervous system is urgent. Objectives was to determine the diagnostic and prognostic value of the NSE marker in children with COVID-19 regarding the complicated course and symptoms of nervous system damage. Materials and methods We conducted a cohort, observational, retrospective study involving 88 children aged 1 month to 18 years with laboratory-confirmed COVID-19 by PCR. Blood serum was collected for the study to assess the level of the neurobiomarker NSE by enzyme immunoassay. We divided patients into two cohorts according to the course of the disease - the main one, which included 42 patients with a complicated course of COVID-19, and a control group - 46 patients with an uncomplicated course of the disease. The study protocol was approved by the Local Ethics Committee of the hospital. Results: In the patients of the control group, NSE was observed at the level of 12.1±1.2 μg/l, while in the children of the main one, the indicator reached 16.9±1.5 μg/l (p=0.087). Increase in the level of NSE above 15 μg/L associated with a significant increase in the risk of the appearance of clinical symptoms of damage to the nervous system and a complicated course in children with COVID-19 (p<0.05). We noted a tendency towards an increase in NSE with increased ESR indicators >10mm/h (p<0.1), a decrease in PTI <85% (p=0,03) and an increase in D-dimer >2.5mg/l (p<0.1). Conclusions We found the diagnostic and prognostic value of the NSE marker in children with COVID-19 regarding the complicated course and symptoms of nervous system damage.Item Preservative-free tafluprost in glaucoma patients with diabetes.(Egyptian Journal of Ophthalmology, 2021-03-11) Veselovskaya, ZoyaItem Real decisions of international medical students on choosing elective courses on general, internal, and evidence-based medicine at Kyiv Medical University(EUROPEAN SCIENTIFIC E-JOURNAL, 2024-07-30) Oleksandr Pokanevych; Borys Ivnyev; Olha PuzanovaSupplementing and improving education content as scientific and subject disciplines emerge is a main principle of curriculum development. Students’ participation in this process is essential for implementing the standard for quality assurance in the European Higher Education Area. Medical students may benefit from gaining more competence in current issues of general, internal, and evidence-based medicine (EBM). The relevance of such elective courses (ECs) for international medical students has not been studied yet according to the literature review. The study object was a methodology for designing a curriculum in the system of higher medical education using a student-centered approach. The study subject was student-related factors influencing curriculum development in terms of making decisions on choosing ECs by international medical students at a clinical department of a medical university. The study aimed to describe features of students’ decisions and determine student-dependent factors regarding the choice of ECs on current issues of general, internal medicine, and EBM by international medical students of Kyiv Medical University (KMU). This explorative, descriptive, comparative cross-sectional pilot study utilized a self-administered web questionnaire, which was answered in April 2024 by 46 international 6th- and 5th-year medical students of KMU coming from eight Asian and African countries (India, Pakistan, Sri Lanka, Iran, Türkiye, Nigeria, Ghana, and Tanzania) and registered in the KMU’s Google Workspace. All participants were divided into three groups according to region: South Asia, West Asia, and West and East Africa. The literature review was performed using information analysis methods. The relevance of all proposed topics for ECs on the issues of EBM, rheumatology, and geriatrics was justified by their choice by all study participants with a frequency of 33,33% to 72,22% in different subgroups and by the average number of topics selected of 1,71 to 2,11 per person. Decisions to choose a course on practicing EBM in internal medicine were more often made by sixth-year students (72,22%) and those coming from South and West Asian countries (73,33% and 80,00%, responsively) than by 5th-year students (46,43%) and Africans (42,31%), whose greatest interest was in aspects of rheumatology. Neither gender factor nor current academic performance in internal medicine influenced students’ decisions regarding the number and topics of ECs. Our study revealed a lack of student initiative concerning individual offering topics for ECs, facts of non-choice of an EBM course in some regional subgroups, like a relatively low frequency of choice of ECs in geriatrics (33,33 and 35,71% among 6th- and 5th-year students, respectively), which confirmed the necessity of the guiding role of teachers in implementing a more student-centered approach in curriculum development and the role of student-dependent factor in this process such as their country of origin. The study results are partly consistent with the literature in terms of the need to study EBM at the undergraduate level of continuing medical education (CME), which can be influenced by national or regional features. The authors conclude that the curriculum content is worth adapting to a more student-centered approach, including the possibility of choosing the current issues in clinical medicine such as the EBM approach, etc. We estimated that the international students’ choice of ECs topics depends on the year of study and the country of origin. The educators should consider the peculiarities of the different countries’ healthcare systems when forming a list of optional educational components for international students in the final years of study.Item Regarding the ways of improving the remote stage of blended learning in teaching the therapeutic discipline(2022) Taktashov H.S.; Hrona N.V.; Voloshyn Ya.V.The use of interactive learning methods will contribute to increasing the level of motivation in the development of professional training skills and student's experience of creative activity that determines the increase in the quality and efficiency of the educational process.Item Relevance of assessing the state of vascular endothelial dysfunction in patients with different courses of chronic rheumatic heart disease(2022) Taktashov H. S.; Hrona N.V.; Zharka A. Yu.The course of rheumatic heart diseaseis closely related to the changes in the levels of vasoconstrictors and vasodilators in the body caused by vascular endothelial dysfunctionthat depends on individual manifestations of the disease, determines by violations of the physical-chemical adsorption-rheological properties of blood and their lipid components.Item Rheumatic diseases: basics of diagnosis(2020) Puzanova O.H.; Batushkin V.V.The Standards and Guidlines for Quality Assurance in the European Higher Education Area include ensuring the quality of training and teaching, creating a wide base of advanced knowledge and competencies, improving curricula, and using flexible learning path and innovation in forms and methods of providing educational sevices. This is consistent with the principle of continuing education and confirms the need to improve methodologicfl support on arduous practical issues, especially at the undergraduate stage, in the residecy and primary care. Among such tasks, diagnostics of rheumatic diseases occupies a special place. The book's content correspods to the requirements of the curriculum in the discipline "Internal medicine" for medical students of higher education institutions. Both history of the description of rheumatic diseases and anatomy and physiology of the muscluloskeletal system are presented briefly, whereas semiotics, methodology and practical aspects of the examination and evaluation of a patient with muscluloskeletal symptoms or suggested rheumatic disease are described in details. Relevant international guidelines are also given. Educational material is submitted in accordance with the principles of practical orientation, optimal sufficiency, and the approaches such as systemic scientific, propaedeutic, consistent, autonomous, competence-based, and evidence-based. Complex didactic material is presented by theoretical information, demonstrated examples, questions and review test items for self-control. There are 25 tables and 23 figures in the book. Intended for medical students of the 5th and 6th years and postgraduates of an English-language form of training, as well as for continuing medical education of the genegal practitioners-family doctors, internists, rheumatologists, and orthopedic traumatologists.Item Structure of Neurological Complications in Children with Covid-19: A Mini-Review and Own Experience(2022-08-16) Sergiy Kramarov; Iryna Seriakova; Vitalii Yevtushenko; Oleksandr Voronov; Oleksandr Buts; Hanna Zaslavska; Inna Grynevych; Natalia KyzymaAim: Aim of this study was to investigate the features of neurological symptoms in pediatric patients hospitalized during the COVID-19 pandemic in 2020-2022 and to analyze similar symptoms according to the literature. We retrospectively investigated 945 cases of the disease in children aged from birth to 17 years, who were hospitalized in KCCCIDH in Kyiv, Ukraine with a diagnosis of coronavirus in the period from June 2020 to February 2022. Among them, cases with neurological symptoms were analyzed. Peculiarities of the clinical picture and results of laboratory researches were determined. To conduct a statistical study of the results, we used the statistical package Statistical software EZR v. 1.54. Results: Neurological symptoms were observed in 142 (15%) patients. Of these, the most numerous was the group of children aged 10 to 18 years, was 55.6% (79/142). The leading neurological symptoms in children were headache (11.7%), ageusia, anosmia (7%), convulsive syndrome (1.2%), acute polyneuropathy (1.2%) and myalgia/arthralgia (3.7%). Among the laboratory data, we found prognostic value for the appearance of neurological symptoms in leukocytes (0.706; 95% CI 0.443-1.124), C-reactive protein (0.708; 95% CI 0.410-1.220) and procalcitonin (0.33; 95% CI 0.21-0.47). Conclusion: Neurological symptoms are a common manifestation in children in the acute period of coronavirus disease. Further monitoring and control studies are needed to cover the acute onset of neurological symptoms, the results of the neurological examination, the rate of progression and the long-term consequences of nervous system disorders in children with COVID-19.