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Analysis are of the hidden properties of the macromolecular system as an example of the reaction centers of bacteria Rhodobacter sphaeroides
(Analytical and Bioanalytical Chemistry, 2019-09-17) Serdenko, T.V
Relevant: Is the study of the response of biological macromolecules to external stimuli. Often the reaction of macromolecules has an effect of structural self-regulation. In this case, their reaction is not only external infl uence, but also the spatial-temporal motions of the macromolecule. In this situation deserves the attention of electronic-conformational interactions of macromolecules. As objects are isolated Reaction Centers (RC) of bacteria Rhodobacter sphaeroides, the structure of which is well studied. During prolonged illumination, the RC occurs intramolecular electron transfer of RC, the kinetics of which has expressed as a sum of three different exponential functions with negative values decrements. In this case, can considered two models of electron transfer with variable or constant with time of the kinetic parameters. Problem: Arises of analyzing the kinetics of electron transfer, which infl uenced by the latent parameters of the RC protein structure, which are diffi cult to determine in the experiment. Aim: Of the work is to determine the features of intramolecular electron transfer between the conformational states of RC, which are associated with a change in the structure of the macromolecule. Result: It was determined that the position of the maxima of the wavelet transform spectrum of the logarithmic derivative of the electron transfer kinetics corresponded to the minimax values of the time dependence of the probability density of the presence of an electron in various redox-conformational states of the RC (population of redox states). Minimax values of the population of RC states corresponded to: 1–6s, 30–60s, 100–140s for various parameters of RC photoexcitation. Conclusion: That the existence of minimax values of the probability density is the electron in the conformational states of the RC can related to the effects of structural self-regulation of the electron transfer process.
Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate
(The Scientific World Journal, 2016) Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar, Olexandr V. Ogloblya, Volodymyr K. Rybalchenko
In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative colitis (UC) model was aimed to be discovered. The anti-inflammatory effects of MI-1 (2.7 mg/kg daily) compared to reference drug Prednisolone (0.7 mg/kg daily) after 14-day usage were evaluated on macro- and light microscopy levels and expressed in 21-grade scale. Redox status of bowel mucosa was also estimated. It was shown that in UC group the grade of total injury (GTI) was equal to 9.6 (GTIcontrol = 0). Increase of malonic dialdehyde (MDA) by 89% and protein carbonyl groups (PCG) by 60% and decrease of superoxide dismutase (SOD) by 40% were also observed. Prednisolone decreased GTI to 3 and leveled SOD activity, but MDA and PCG remained higher than control ones by 52% and 42%, respectively. MI-1 restored colon mucosa integrity and decreased mucosa inflammation down to GTI = 0.5 and leveled PCG and SOD. Thus, MI-1 possessed anti-inflammatory properties, which were more expressed that Prednisolone ones, as well as normalized mucosa redox balance, and so has a prospect for correction of inflammatory processes.
Blockade of L-type calcium channels alters hepatic mitochondrial function in insulin-resistant rats
(Фізіологічний журнал, 2023-09-04) Zavhorodnii, M.O.; Nosar, V.I.
Mitochondria are central organelles in maintaining energy and oxidative homeostasis. Despite intensive research, the function of mitochondria and the mechanisms of its regulation under physiological conditionsand in insulin resistance require detailed investigation. The aim of this study was to investigate the effect of blockade L-type calcium channels in insulin-resistant rats on hepatic mitochondrial oxidative function and changes in its oxidative status. Insulin resistance was modeled in 6-month-old male Wistar rats by 14 days of high-fat feeding. Standard fed animals served as controls. Verapamil was administered intraperitoneally at a dose of 1 mg/kg to block L-type calcium channels. Indicators of pro- and antioxidant systems (active products of tiobarbituric acid, reduced glutathione, catalase, Cu,Zn-superoxide dismutase) were assayed in the liver homogenate extracted from anesthetized animals after 3 h. Mitochondrial function was studied by the Chance polarographic method using different metabolic substrates. It was shown that in intact animals blockade of L-type calcium channels reduced the efficiency of mitochondrial respiration (V3/V4) in liver mitochondria during oxidation of all substrates through an inhibitory effect on the phosphorylation respiration (V3) and a stimulatory effect on the controlled respiration (V4), without affecting the oxidative status of the liver. In rats with insulin resistance the rate of V3 during oxidation of both NAD- and FADdependent substrates was decreased, violations of oxidative status and increased antioxidant protection were detected. However, in insulin-resistant rats blockade of L-type calcium channels significantly enhanced basic respiration (V2) during NAD-dependent substrate oxidation, V3 and V4 during palmitoyl lipid substrate oxidation, reduced the V3/V4 ratio compared to control, and partially or fully restored the violation of the oxidative status. This may indicate the involvement of calcium mechanisms in the disturbance of the oxidative status of the liver and the regulation of energy metabolism in mitochondria during insulin resistance.
Chronic pain in Parkinson disease
(Journal of Education, Health and Sport, 2020-05-29) Palamarchuk,A
The study was aimed to assess the modern trends explaining pathogenesis of chronicpain amongst patients with PD. The information search in the open sources was conducted using databases OVID, PubMed and EMBASE, the depth of search was in time frame after 2010. Content analysis was provided for the most pertinent literature reviews and clinical trials. There were selected 12 sources amongst 89 primary found references.There were discussed the main domains of pathogenesis of chronic pain in Parkinson disease. The approaches to pain management in PD patients primarily depend on the underlying cause. The presence of chronic pain syndrome should be considered as a reason for assessing the adequacy of antiparkinsonian therapy
COGNITIVE FUNCTIONS IN MULTIPLE SCLEROSIS PATIENTS DEPENDING ON THE DIFFERENT RISK FACTORS PRESENCE
(ALUNA, 2021-10) Kopchak Oksana; Odintsova Tetiana; Pulyk Oleksandr
The aim: To clarify the influence of different risk factors on cognitive impairment (CI) in general and in separate domains and their association with MRI findings in patients with relapsing-remitting (RRMS) and progressive forms of multiple sclerosis (SPMS and PPMS). Materials and methods: One hundred and thirty-seven participants with MS (102 females and 35 males) aged from 22 to 69 years were enrolled into this study. All patients completed the Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A) and undergone MRI. Results: According to MS phenotypes all participants were divided into two groups: patients with RRMS (n= 106) and with progressive phenotypes (n= 31). A significant positive correlation was present between MoCA and BDI scores in all participants (p= 0,0015). Presence of anxiety did not demonstrate any valid influence on cognitive performance, although severe anxiety was significantly more often found in subjects with progressive phenotypes in presence of brain atrophy (p= 0,0028). Patients with higher education had no CI more frequently compare to those without it (p= 0,0019), whereas, participants smoking cigarettes had higher prevalence of severe CI than non-smokers (p= 0,0061). Conclusions: Among cognitive domains memory, visual-spatial and executive functions, abstract thinking were impaired the most in MS patients, though abstract thinking was more often affected in progressive forms. The results demonstrated that physical disability, depression and smoking negatively impacted cognitive performance, meanwhile presence of higher education demonstrated a favorable influence on cognition in MS patients.
Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings
(Springer Nature, 2021-09-08) Kopchak Oksana; Odintsova Tetiana
Background: Multiple sclerosis is an insidious, disabling, both physically and mentally, demyelinating disease of the central nervous system. This work aims to evaluate relationships between cognitive impairment in separate domains, depression and their correspondence with MRI-fndings, as well as the infuence on each other’s manifestations, in patients with relapsing–remitting multiple sclerosis. Results: Visual–spatial/executive functions and memory domains sufered more frequently than others in the study subjects under 40 years; in patients over 40 years old memory, visual–spatial/executive functions and abstract thinking impairment prevailed the most. Such cognitive domains as memory, language, abstract thinking, visual–spatial and executive functions were impacted in both groups of patients even without the apparent cognitive decline according to MoCA scale. Presence of depression impacted language and attention more prominently than the rest of the domains only in participants younger 40 years. According to the MRI, frontal lobe, corpus callosum and periventricular area were afected more often compared to other brain regions in case of cognitive impairment; meanwhile, combined lesions of frontal lobe and corpus callosum, fronto-temporal region were associated with depression. Conclusion: Cognitive impairment and depression are one of the common, yet disabling and socially disrupting manifestations of MS. Quite frequently such complaints are neglected or considered as parts of comorbidities. At the same time cognitive impairment can be amplifed by depression, especially in patients under 40 years.
Echinacea Angustifolia and its influence on SARS viruses
(Київський медичний університет, 2022) Kolinko, Y.I
Introduction: Coronavirus or Covid 19 is a type of acute respiratory syndrome with a viral agent of the coronavirus family that causes lung disease, inflammation and apoptosis in humans and sometimes causes death in humans with weakened immune system. In this article, the active ingredients of Echinacea plant, which increases the resistance of the body's immune system and, which ultimately leads to the prevention and treatment of disease, have been studied.
EMOTIONAL IMPACT OF THE COVID-19 PANDEMIC ON HEALTHCARE WORKERS IN UKRAINE
(Aluna Publishing, 2022-05) Pinchuk Irina; Pishel Vitaliy; Polyvіanaia Marina; Kopchak Oksana; Chumak Stanislav; Filimonova Natalia; Yachnik Yuliaya
Objective: The aim: To study the emotional impact of the COVID-19 pandemic on healthcare workers in Ukraine. Patients and methods: Materials and methods: 1087 healthcare workers across all regions of Ukraine completed an online questionnaire. Respondents were divided into two groups: A - 863 (79.4%), В - 224 (20.6%), according to whether or not they experienced anxiety/fear related to COVID-19. Results: Results: Such factors as risk of contracting COVID-19, news of new cases, insufficient staff in healthcare facilities, risk of transmission of COVID-19 to family or friends, risk of death from COVID-19, the threat of the spread of the COVID-19 pandemic were associated with high level of anxiety/fear among healthcare workers. Factors that facilitate coping with stress included absence of Covid-19 cases among staff, recovering patients, availability of gear and protective equipment and absence of COVID-19 infected among loved ones, relieving stress (relaxation, going info sports and so on), communication with family and friends to relieve stress and get support, avoidance of COVID-19 media reports in particular on deaths connected cases, getting information about the spread of Covid-19 only from legitimate sources. Conclusion: Conclusions: The data obtained in this study indicate an urgent need for the development and implementation of preventive and rehabilitation measures aimed at stabilizing the psycho-emotional state of health workers and improving the quality of care in the special conditions of the COVID-19 pandemic. Achieving these goals will be facilitated by taking into account the specifics of the response to COVID-19 and measures to reduce the effects of stress while enhancing the effects of stressors among health care workers.
FEATURES OF GUT MICROBIOTA IN PATIENTS WITH MIGRAINE AND HEALTHY INDIVIDUALS
(Tbilisi State Medical University, 2022) Kopchak O.; Hrytsenko O.
The gut – brain axis plays a significant role in the pathophysiology of migraine. This interaction can be influenced by multiple factors, such as gut microbiota profiles. Background/Objectives: The aim of the study was to analyze the gut microbiome state in patients with migraine and healthy individuals, to assess possible correlations between the detected changes in patients with migraine and the frequency, intensity of headaches, their psycho-emotional state, and quality of life. Subjects/Methods: In total, 112 patients-16.3% of men and 83.7% of women. Subjects were divided into 2 groups depending on the presence of migraine: the main - patients with chronic and episodic forms of migraine, the control - healthy individuals. The study of the intestinal microbiome was performed by chromato-mass spectrometry. The following scales were used: Visual Analogue Scale/VAS, Migraine Disability Assessment/ MIDAS, Back Depression Inventory/BDI. Results: In patients with migraine compared with healthy individuals, significant changes were noted in the quantitative composition of certain resident microorganisms including Alcaligenes spp (p=0.0061), Clostridium coccoides (p=0.0021), Clostridium propionicum (p=0.0287), Eggerthella lenta (p=0.0138), Pseudonocardia spp (p=0.0210), and Rhodococcus spp (p=0.0164). The number of microscopic fungi such as Candida spp (p=0.0079), Micromycetes spp (p=0.0011) and Micromycetes spp (p=0.0010) were increased in patients with migraine compared to the control group. In the main group, a negative correlation was found between the level of Alcaligenes spp and the score on the BDI score, HARS score (respectively: r= -0.6226, p= 0.007; r= -0.509, p=0.03), the frequency of attacks (r=-0.4879, p=0.046) and the VAS score (r=-0.487, p=0.046). Significant negative correlation was found between elevated level of Clostridium coccoides and MIDAS score (r=-0.5123, p=0.03), BDI score (r=-0.54, p=0.025) in the patients with migraine. At the same time, in the main group a positive correlation was detected between Eggerthella lenta level of and VAS score (r=0.4830, p=0.049). In the main group negative correlations were found between slightly increased content of endotoxin in the main group, the BDI score, HARS score (respectively: r=-0.697, p=0.001; r=-0.557, p=0.02) the frequency of attacks (r=-0.547, p=0.023), on the VAS score (r=-0.531, p=0.028), as well as MIDAS score (r =-0.556, p=0.02). Conclusion: The revealed peculiarities of gut microbiome changes in patients with migraines need further clarification in order to identify the possible role of the gut microbiome in the pathogenesis, clinical picture, and therapy of migraine, and is a promising area of further scientific research.
Influence of an epigenetic diet on migraine patients
(AMPH, 2022-11-09) Kopchak Oksana; Hrytsenko Olena
Objective. Migraine is a common type of primary headache disorder, distinguished by recurrent attacks of moderate to severe unilateral throbbing pain. The goal of this study is to analyze the epigenetic influences of diet and their effects on patients with migraine headaches. Materials and methods. 130 patients with migraine headaches were analyzed (13.7% male and 86.3% female). The subjects were divided into two groups; Group A patients subsequently followed an epigenetic diet enriched with 5 mg of folic acid. Group B patients didn’t follow any type of diet. Results. When analyzing the data before the start of the study, it was found that the average concentration of folic acid in Group A was 2.8+3.6 ng/ml, which was significantly lower than in Group B (p=0.003). The average level of homocysteine was significantly different in both groups (р=0.04). Furthermore, a significant decrease in the intensity and frequency of headache was found (р = 0.02; р = 0.04), and a decrease in the average level of anxiety according to the Hamilton Anxiety Scale was found (from 15.0+3.5 points to 9+2 points) (p=0.03). Conclusion. A significant effect from homocysteine and folic acid levels in migraine patients on headache severity and quality of life was observed.
Influential Modifications of the Genre System of Modern Mass Media
(SC INMANIFEST NETWORK SRL, In Manifest Network Publishing, 2022) Stiekolshchykova V., Savchuk R., Makarchuk O., Filatenko I., Humanenko O., Shoturma N.
The article is devoted to the consideration of the issue of influential modifications of the genre system of modern mass media. It has been established that the mass media are one of the main means of communication for the wide audience. The meaning of the words "modification", "mass media", "mobile journalism", "new media" has been studied. The article notes that "new media" appeared in the 60s of the XX century. The main characteristics of the media are presented. It is noted that the most common examples of mass media are television, radio, newspapers, magazines, social media, digital media, the Internet. The textbooks and publications of domestic and foreign scientists, which raise the issue of influential modifications of the genre system of modern mass media are highlighted. It was found that the first media were newspaper, telegraph, radio, television. The study of the main types of media is emphasized: traditional media, print media, electronic broadcasting media, external media, transit media and new media. It is noted that new media is a reconceptualization of traditional media. The aspect of media in the role of a social institution has been studied. It was noted about the significant impact of digitalization on the global media system. The significant influence of the use of the Internet in the political life of the United States is given as an illustrative example. The use of the "video story" technology as one of the strategies for holding the attention of the reader or listener is considered. The focus is on the interactive storytelling made possible by digital media and provides advantages for interactive television and cinema, as well as helping to create virtual and mixed reality in games, contributing to the emergence of new forms of voice games.
METHODOLOGICAL PRINCIPLES OF TEACHING THE DISCIPLINE "HUMAN ANATOMY" TO STUDENTS OF HIGHER MEDICAL INSTITUTIONS IN THE REALITIES OF TODAY
(Proceedings of the III International Scientific and Practical Conference. Sofia, Bulgaria, 2024-09-17) Mykhailiuk Mykhailo; Kovalchuk Nataliya; Yevtushenko Viacheslav
This paper focuses on the peculiarities of teaching the fundamental discipline "Human Anatomy" to 1st year students in higher medical institutions. Attention is focused on the author's own experience of teaching the basic discipline "Human Anatomy" to medical students and, based on the analysis, the main ways to improve and enhance the presentation of the material, taking into account the psychological stability of students in today's conditions, are formed. Particular attention is paid to the importance of communicative culture in the university environment, in particular, communication between student and teacher (dialogue, feedback, etc.).
MODIFICATIONS OF LOWER LIMBS CENTRAL AND PERIPHERAL HEMODYNAMICS DUE TO INTERMITTENT PNEUMATIC COMPRESSION EFFECTS
(SÉRIE“Lékařské vědy”, 2023-03-26) Palamarchuk, Andrii; Shesterina, Daria
Abstract. High prevalence of cardiovascular diseases [1] implies continuous improvement of noninvasive physical techniques particularly perfectioning of compression therapy techniques [2]. Intermittent pneumatic compression (IPC) widely used thought multipurpose physical rehabilitation in vascular surgery, dermatologic surgery, and sport medicine (Wesley C. et al. 2015). Compression therapy (CT) is an established treatment method with very low rate of complications in research various facets of vascular and skeletal muscle physiology [3]. However, despite the widely accepted usage of IPC, the exact consensus on the IPC pressure and time parameters is not established yet. The study was aimed to evaluate hemodynamic effects of intermittent pneumatic compression on the lower extremities and identify most effectiveness external pressure parameter and optimal procedure timing. The study was included healthy 30 volunteers, 17+ years of age. Vascular assessment included determination of the resting ankle-brachial pressure index (ABI) and entered into intermittent pneumatic pressure correction program. According of ABI pressures of 40,80, and 100 mmHg, and the procedure time limit at 20 minutes were applied. Outcome was considered succeed if blood pressure was dropped during and after procedure by increasing the expelled blood volume flow during a given period. To investigate the blood flow velocity during IPC, impedance cardio-vasography (ICVG) was implied. A summary of the 20-minute testing with different IPC of pressure indicators in the chambers led to the following outcomes. Correlational analysis of systolic-diastolic index with the maximum value of systolic amplitude manifested minor changes [0,3886±0,02157 (mean ± SD)] from the respective rest value. The amplitude of the systolic wave, which is mainly determined by the pulse blood filling, increases [0,1661±0,02959 mean ± SD)] from the respective rest value that is, the larger the volume of the muscle tissue blood filling per unit time. The increase time of fast blood filling and systolic amplitude for about 15 and 20 minutes of recovery after procedure was observed to be statistically significant (the correlation coefficient is 0.7705). Peaks in the low frequency (LF) ranging from 0.04 Hz to 0.15 Hz is were increase for about 5-10 min in recovery period. The low frequency/high frequency ratio, which consists of the ratio of the powers is used to quantify the sympathovagal balance.IPC devices for prevention hypertension is gradually becoming a standard second-order therapy, for instance, in particular, for patients with a high risk of bleeding. However, further studies for determining a more accurate time of inflation and deflation in the chambers of IPC devices are required
PATHOGENETIC MECHANISMS OF CONVULSIVE DEPRESSIVE SYNDROME IN THE CONDITIONS OF KINDLING-INDUCED MODEL OF EPILEPTOGENESIS
(Світ медицини та біології, 2020-03-29) Bibikova, V.O.; Vastyanov, R.S
Non-convulsive behavioral disorders are registered in the majority (over 75 %) of patients with epilepsy and are most often the only and most prominent manifestation of this disease. However, the neuropathogenetic mechanisms of these behavioral disorders remain insufficiently studied in the dynamics of chronic epileptogenesis, and the question of pathogenetically determined correction of non-convulsive epileptiform behavioral disorders is not considered in terms of comprehensive treatment of the chronic convulsive syndrome. The purpose of our work was to study the dynamics of the postural behavior severity in rats under the conditions of different periods of formation of picrotoxin-induced kindling using the striatal functional activity modulation. The obtained data indicate the hyperactivation of the striatum under the conditions of the development of picrotoxin-induced chronic convulsive activity, which functional activity depends on the term of the convulsive syndrome manifestation. The study of non-convulsive types of motor, emotional, swimming, cognitive behavior and their disorders during the specified time intervals of the formation of chronic epileptic activity is important for the use of certain behavioral disorders as an early diagnosis of epilepsy when the motor seizure disorders are absent and the probable behavior disorders do not reach maximum intensity
PECULIARITIES OF THE GUT MICROBIOTA IN PATIENTS WITH MIGRAINE COMPARING TO HEALTHY INDIVIDUALS
(Aluna Publishing, 2022-09) Kopchak Oksana; Hrytsenko Olena; Pulyk Oleksandr
The aim: Analyze the gut microbiome state in patients with migraine (M) and healthy individuals, to assess possible correlations between the detected changes in patients with migraine and the frequency, intensity of headaches, psycho-emotional state of the patients, and their quality of life. Materials and methods: 100 objects were enrolled, divided into 2 groups: main – patients with M and control – healthy volunteers. Investigation of the intestinal microbiome was performed by chromato-mass spectrometry. For M patients the following scales were used: Visual Analogue Scale (VAS), Migraine Disability Assessment (MIDAS), Back Depression Inventory (BDI). Results: In main group increased amount of Alcaligenes spp (p = 0.0061), Clostridium coccoides (p = 0.0021), Clostridium propionicum (p = 0.0287), Eggerthella lenta (p = 0.0138), Pseudonocardiaspp (p = 0.0210),Rhodococcus spp (p = 0.0164), Candidaspp (p = 0.0079), Micromycetes spp(campesterol) (p = 0.0011) were found. Patients with M had a raised amount of Herpes simplex (p = 0.0305) and endotoxin level (p = 0.0459). Differences in gut microorganisms in both groups were significant. In patients with M negative correlations were observed between Alcaligenes spp ammount and BDI score (r = -0.6226, p =0.007), VAS score (r = -0.489, p = 0.046), headache frequency (r = -0.487, p = 0.046); between the levels of Clostridium coccoides and MIDAS score (r =-0.51, p = 0.035), BDI score (r = -0.54, p = 0.025) and positive correlation between Eggerthellalenta level and VAS score (r =0.4830, p=0.049). Conclusions: Correlations between changes of gut microbiome and M are promising for further research.
Predicting cognitive impairment and psycho-emotional disorders in Multiple Sclerosis patients according to MRI findings
(AMPH, 2022-12-30) Odintsova Tetiana; Kopchak Oksana
Objectives. The aim of our study was to assess the probability of cognitive impairment (CI) in general and in separate domains, depression, anxiety and sleep disorders onset depending on their association with MRI findings in patients with multiple sclerosis (MS). Materials and methods. 137 patients with MS were enrolled into the study. All participants were divided into two groups: group A included study subjects with relapsing remitting multiple sclerosis (RRMS) and B consisted of patients with secondary progressive multiple sclerosis (SPMS). Results. Participants with progressive forms of MS had a higher risk of CI development compare to the patients with RRMS (p=0,0361). Memory decline onset depended on the presence of the brain atrophy in combination with lesions of the parietal lobe (OR=2.74 (0.85-8.77), p <0.0001) in RRMS cases, furthermore, on presence of combined demyelination in temporal lobe with corpus callosum (OR=17.33 (2.92-103.02), p=0.0006) and parietal lobe separately (OR=7.5 (1.14-49.26), p=0.0239) in patients with SPMS. Conclusions. CI and psycho-emotional disorders can be predicted by means of MRI findings and potentially prevented.
Prevalence of sexual disorders in relapsing-remitting multiple sclerosis patients depending on various risk factors
(AMPH, 2024) ODINTSOVA Tetiana; KOPCHAK Oksana
Objective. Multiple sclerosis is a perilous, disabling, physically as well as mentally, demyelinating disease of the central nervous system. This work aims to evaluate prevalence of sexual dysfunctions and their correspondence with non- and disease related risk factors, as well as with MRI findings in patients with relapsing-remitting multiple sclerosis. Results. Based on conducted multifactorial analysis, the most prominent risk factor associated with presence of sexual dysfunctions in in patients with relapsing-remitting multiple sclerosis was depression. Sexual dysfunctions are tied to cognitive deficit, in general and in separate domains, particularly in memory, executive functions and language. Considering disease-related agents, sensory and motor deficits are linked to the development of sexual dysfunctions in case of relapsing-remitting multiple sclerosis. Among nondisease-related factors, unemployment, marital status, level of education and tobacco smoking are affecting sexual dysfunctions’ severity. According to the MRI, frontal lobe and corpus callosum and periventricular area were affected more often comparing to other brain regions in case of sexual dysfunctions. Conclusions. Patients suffering from relapsing-remitting multiple sclerosis encounter secondary and tertiary sexual dysfunctions. Knowing all struggles of MS, patients should be offered more nuanced management options that will improve their quality of life on a deeper level.
PROGNOSTIC ASSESSMENT OF STRESS-RELATED FACTORS IN HEALTHCARE WORKERS DURING THE COVID-19 PANDEMIC
(Medicinska naklada, 2022) Pinchuk Irina; Pishel Vitaliy; Chumak Stanislav; Ilnytska Tetiana; Stepanova Nataliia; Filimonova Natalia; Kopchak Oksana; Yachnik Yulia; Kolodezhny Oleksiy; Solonskyi Andrii
Introduction: The COVID-19 pandemic is an extraordinary challenge for all countries and affects the psychological wellbeing of healthcare professionals working with people suffering from COVID-19 and puts them at a high risk of mental health problems. The aim of the study was to identify stress-related factors that affect the mental health of healthcare workers during the COVID-19 pandemic in Ukraine. Subjects and methods: A total of 1098 Ukrainian healthcare workers were surveyed using an online questionnaire consisting of questions relating to a) socio-demographic characteristics; b) perceptions of the COVID-19 related situation; and c) stress and protective factors. Respondents were divided into two groups, depending on whether they provided care to the patients with COVID-19 or not. Results: Of the 1087 healthcare workers, 863 (79.4%) were found to have anxiety / fear caused by the COVID-19. No significant difference was detected between professionals who did and did not provide personal assistance to patients with COVID-19 concerning anxiety / fear related to COVID-19 the most significant predictive factors for anxiety / fear caused by the COVID-19 were factors related to safety and risk perception (the risk of getting infected, dying, infecting loved ones, perception of the threat of the epidemic spread), information factors (constant news about COVID-19), as well as factors related to the organisation of care (lack of staff in health care facilities). Conclusions: Negative risk perception, high consumption of COVID-19 news, and shortage of staff in health care facilities were significant predictors of anxiety / fear caused by the COVID-19.
Pros and cons of remote medical education in Ukraine in terms of COVID-19 pandemics
(Elsevier Ltd., 2022-08-24) Kopchak Oksana; Odintsova Tetiana; Bachinskaya Nataliya; Ivniev Borys; Pokanevych Oleksandr
Introduction: COVID-19 is an ongoing pandemic, which forced countries across the globe to adapt all daily activities to the new reality in order to stop the disease from spreading. The educational process was not an exception, it caused a sudden shift towards the exceptional introduction of online teaching and Kyiv Medical University was one of the first universities in Ukraine to assess the quality of education under the restrictive measures Objectives: The aim was to analyze the advantages and disadvantages of online education during the COVID-19 pandemic in the learning of neurology at the Department of Neurology, Psychiatry and Physical Rehabilitation, Kyiv Medical University. Methods: 169 students were interviewed using an online questionnaire consisting of 18 items focused on different angles of educational process. Results: According to the obtained results, the biggest pros of online teaching included: flexibility of learning schedule, learning at your own pace; ability to develop deeper problem-solving and clinical thinking skills. Social distancing, family distractions, and internet connection issues negatively affected most students’ feelings during online learning. One of the most prominent cons of online learning of neurology pointed out by the majority of medical students was a lack of practical component of training and contact with patients. Conclusions: Online teaching, along with a number of advantages, has significant disadvantages, especially in medical education in case of studying clinical disciplines
Psychological well-being of Ukrainian students three months after the emerge of full-scale war
(Polish Psychiatric Association Editorial/Publishing Commitee, 2024) Pinchuk Irina; Solonskyi Andrii; Yachnik Yuliia; Kopchak Oksana; Klasa Katarzyna; Sobański Jerzy; Odintsova Tetiana
Aim. To depict overall psychological well-being of a large group of students of different universities in Ukraine three months after the emerge of the full-scale war. Material and methods. A total of 1,142 participants were asked to measure their psychological well-being on a 0–10 scale before and after the onset of full-scale war. Mental health symptoms were measured with questionnaires targeting depression (PHQ-9), anxiety (GAD-7), sleep problems (ISI), eating disorders (SCOFF), alcohol abuse (CAGE), and PTSD symptoms (PC-PTSD-5). To evaluate the connection between variables a χ2 was conducted. Phi and Cramer’s V coefficient were stated to demonstrate the power of the relationships. Additionally, machine learning (the XGBoost regression model) was used to build a predictive model for depressive symptoms. Results. Of all respondents, 66% screened positive for PTSD symptoms, 45% – moderate and severe anxiety symptoms, 47% – moderate and severe depressive symptoms. Regarding sleep, alcohol use and eating behavior, 19% of surveyed students had signs of moderate and severe insomnia, 15% reported alcohol abuse and 31% disordered eating. The severity of the aforementioned disorders varied depending on gender, year of study, social status, etc. According to the predictive model, lower initial psychological well-being, female gender, younger age, first years of study and any traumatic experience, including multiple trauma, predicted increases in depression score. Return to home after relocation was a protective factor. Conclusions. The study demonstrated the high prevalence of mental health symptoms among university students in Ukraine during the first months of the full-scale war. The psychological well-being pre-war was the strongest predictor of depressive symptoms in the model.

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