Міжнародний факультет

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An interdisciplinary teaching approach (on the example of class and remote learning component 1994–2023 years) (author’s experience)
(Baltija Publishing, 2023-11-02) Korniienko, Oleksiy; Корнієнко, Олексій Васильович
The abstract examines the author's 30-year experience (1994–2023) in implementing an interdisciplinary approach to teaching medical psychology. The study analyzes the evolution of teaching methods from traditional classroom formats to modern blended and distance learning models. The author highlights the importance of integrating psychological knowledge with clinical practice to improve the quality of medical education and professional training for future doctors in both offline and online environments. У тезах розглядається авторський 30-річний досвід (1994–2023 рр.) впровадження міждисциплінарного підходу у викладанні медичної психології. Аналізується еволюція методик від традиційного аудиторного формату до сучасних моделей змішаного та дистанційного навчання. Автор наголошує на важливості інтеграції психологічних знань із клінічною практикою для підвищення якості підготовки майбутніх лікарів як в офлайн, так і в онлайн середовищах.
Analysis are of the hidden properties of the macromolecular system as an example of the reaction centers of bacteria Rhodobacter sphaeroides
(Analytical and Bioanalytical Chemistry, 2019-09-17) Serdenko, T.V
Relevant: Is the study of the response of biological macromolecules to external stimuli. Often the reaction of macromolecules has an effect of structural self-regulation. In this case, their reaction is not only external infl uence, but also the spatial-temporal motions of the macromolecule. In this situation deserves the attention of electronic-conformational interactions of macromolecules. As objects are isolated Reaction Centers (RC) of bacteria Rhodobacter sphaeroides, the structure of which is well studied. During prolonged illumination, the RC occurs intramolecular electron transfer of RC, the kinetics of which has expressed as a sum of three different exponential functions with negative values decrements. In this case, can considered two models of electron transfer with variable or constant with time of the kinetic parameters. Problem: Arises of analyzing the kinetics of electron transfer, which infl uenced by the latent parameters of the RC protein structure, which are diffi cult to determine in the experiment. Aim: Of the work is to determine the features of intramolecular electron transfer between the conformational states of RC, which are associated with a change in the structure of the macromolecule. Result: It was determined that the position of the maxima of the wavelet transform spectrum of the logarithmic derivative of the electron transfer kinetics corresponded to the minimax values of the time dependence of the probability density of the presence of an electron in various redox-conformational states of the RC (population of redox states). Minimax values of the population of RC states corresponded to: 1–6s, 30–60s, 100–140s for various parameters of RC photoexcitation. Conclusion: That the existence of minimax values of the probability density is the electron in the conformational states of the RC can related to the effects of structural self-regulation of the electron transfer process.
Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate
(The Scientific World Journal, 2016) Halyna M. Kuznietsova, Maryna S. Yena, Iryna P. Kotlyar, Olexandr V. Ogloblya, Volodymyr K. Rybalchenko
In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative colitis (UC) model was aimed to be discovered. The anti-inflammatory effects of MI-1 (2.7 mg/kg daily) compared to reference drug Prednisolone (0.7 mg/kg daily) after 14-day usage were evaluated on macro- and light microscopy levels and expressed in 21-grade scale. Redox status of bowel mucosa was also estimated. It was shown that in UC group the grade of total injury (GTI) was equal to 9.6 (GTIcontrol = 0). Increase of malonic dialdehyde (MDA) by 89% and protein carbonyl groups (PCG) by 60% and decrease of superoxide dismutase (SOD) by 40% were also observed. Prednisolone decreased GTI to 3 and leveled SOD activity, but MDA and PCG remained higher than control ones by 52% and 42%, respectively. MI-1 restored colon mucosa integrity and decreased mucosa inflammation down to GTI = 0.5 and leveled PCG and SOD. Thus, MI-1 possessed anti-inflammatory properties, which were more expressed that Prednisolone ones, as well as normalized mucosa redox balance, and so has a prospect for correction of inflammatory processes.
Blockade of L-type calcium channels alters hepatic mitochondrial function in insulin-resistant rats
(Фізіологічний журнал, 2023-09-04) Zavhorodnii, M.O.; Nosar, V.I.
Mitochondria are central organelles in maintaining energy and oxidative homeostasis. Despite intensive research, the function of mitochondria and the mechanisms of its regulation under physiological conditionsand in insulin resistance require detailed investigation. The aim of this study was to investigate the effect of blockade L-type calcium channels in insulin-resistant rats on hepatic mitochondrial oxidative function and changes in its oxidative status. Insulin resistance was modeled in 6-month-old male Wistar rats by 14 days of high-fat feeding. Standard fed animals served as controls. Verapamil was administered intraperitoneally at a dose of 1 mg/kg to block L-type calcium channels. Indicators of pro- and antioxidant systems (active products of tiobarbituric acid, reduced glutathione, catalase, Cu,Zn-superoxide dismutase) were assayed in the liver homogenate extracted from anesthetized animals after 3 h. Mitochondrial function was studied by the Chance polarographic method using different metabolic substrates. It was shown that in intact animals blockade of L-type calcium channels reduced the efficiency of mitochondrial respiration (V3/V4) in liver mitochondria during oxidation of all substrates through an inhibitory effect on the phosphorylation respiration (V3) and a stimulatory effect on the controlled respiration (V4), without affecting the oxidative status of the liver. In rats with insulin resistance the rate of V3 during oxidation of both NAD- and FADdependent substrates was decreased, violations of oxidative status and increased antioxidant protection were detected. However, in insulin-resistant rats blockade of L-type calcium channels significantly enhanced basic respiration (V2) during NAD-dependent substrate oxidation, V3 and V4 during palmitoyl lipid substrate oxidation, reduced the V3/V4 ratio compared to control, and partially or fully restored the violation of the oxidative status. This may indicate the involvement of calcium mechanisms in the disturbance of the oxidative status of the liver and the regulation of energy metabolism in mitochondria during insulin resistance.
CHRONIC NON-SPECIFIC LOW BACK PAIN AS A CONSEQUENCE OF FASCIAL FIXATION OF THE SAPHENOUS NERVE IN THE ADDUCTOR CANAL
(«Перспективи та інновації науки» (Серія «Педагогіка», Серія «Психологія», Серія «Медицина»). – 2026. № 5(63) С. 2145-2157., 2026-06-18) Parakhin Andrii Anatoliiovych; Kovalchuk Nataliia Vasylivna; Mykhailiuk Mykhailo Mykhailovych; Yevtushenko Vladyslav Vitaliiovych
The study focuses on the hypothesis that fascial fixation of the saphenous nerve is a significant etiological factor for retrograde pain irradiation to the lumbar spine, mimicking radicular symptoms without structural root compression.
Chronic pain in Parkinson disease
(Journal of Education, Health and Sport, 2020-05-29) Palamarchuk,A
The study was aimed to assess the modern trends explaining pathogenesis of chronicpain amongst patients with PD. The information search in the open sources was conducted using databases OVID, PubMed and EMBASE, the depth of search was in time frame after 2010. Content analysis was provided for the most pertinent literature reviews and clinical trials. There were selected 12 sources amongst 89 primary found references.There were discussed the main domains of pathogenesis of chronic pain in Parkinson disease. The approaches to pain management in PD patients primarily depend on the underlying cause. The presence of chronic pain syndrome should be considered as a reason for assessing the adequacy of antiparkinsonian therapy
COGNITIVE FUNCTIONS IN MULTIPLE SCLEROSIS PATIENTS DEPENDING ON THE DIFFERENT RISK FACTORS PRESENCE
(ALUNA, 2021-10) Kopchak Oksana; Odintsova Tetiana; Pulyk Oleksandr
The aim: To clarify the influence of different risk factors on cognitive impairment (CI) in general and in separate domains and their association with MRI findings in patients with relapsing-remitting (RRMS) and progressive forms of multiple sclerosis (SPMS and PPMS). Materials and methods: One hundred and thirty-seven participants with MS (102 females and 35 males) aged from 22 to 69 years were enrolled into this study. All patients completed the Montreal Cognitive Assessment (MoCA), Beck Depression Inventory (BDI), Hamilton Anxiety Rating Scale (HAM-A) and undergone MRI. Results: According to MS phenotypes all participants were divided into two groups: patients with RRMS (n= 106) and with progressive phenotypes (n= 31). A significant positive correlation was present between MoCA and BDI scores in all participants (p= 0,0015). Presence of anxiety did not demonstrate any valid influence on cognitive performance, although severe anxiety was significantly more often found in subjects with progressive phenotypes in presence of brain atrophy (p= 0,0028). Patients with higher education had no CI more frequently compare to those without it (p= 0,0019), whereas, participants smoking cigarettes had higher prevalence of severe CI than non-smokers (p= 0,0061). Conclusions: Among cognitive domains memory, visual-spatial and executive functions, abstract thinking were impaired the most in MS patients, though abstract thinking was more often affected in progressive forms. The results demonstrated that physical disability, depression and smoking negatively impacted cognitive performance, meanwhile presence of higher education demonstrated a favorable influence on cognition in MS patients.
Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings
(Springer Nature, 2021-09-08) Kopchak Oksana; Odintsova Tetiana
Background: Multiple sclerosis is an insidious, disabling, both physically and mentally, demyelinating disease of the central nervous system. This work aims to evaluate relationships between cognitive impairment in separate domains, depression and their correspondence with MRI-fndings, as well as the infuence on each other’s manifestations, in patients with relapsing–remitting multiple sclerosis. Results: Visual–spatial/executive functions and memory domains sufered more frequently than others in the study subjects under 40 years; in patients over 40 years old memory, visual–spatial/executive functions and abstract thinking impairment prevailed the most. Such cognitive domains as memory, language, abstract thinking, visual–spatial and executive functions were impacted in both groups of patients even without the apparent cognitive decline according to MoCA scale. Presence of depression impacted language and attention more prominently than the rest of the domains only in participants younger 40 years. According to the MRI, frontal lobe, corpus callosum and periventricular area were afected more often compared to other brain regions in case of cognitive impairment; meanwhile, combined lesions of frontal lobe and corpus callosum, fronto-temporal region were associated with depression. Conclusion: Cognitive impairment and depression are one of the common, yet disabling and socially disrupting manifestations of MS. Quite frequently such complaints are neglected or considered as parts of comorbidities. At the same time cognitive impairment can be amplifed by depression, especially in patients under 40 years.
COMMUNICATIVE CULTURE OF THE TEACHER AND THE STUDENT: PECULIARITIES OF FORMATION AND INTERACTION IN CONDITIONS OF UNCERTAINTY ABOUT THE FUTURE
(Міжнародний центр наукових досліджень. —Вінниця: ТОВ«УКРЛОГОС Груп, 2024., 2024-12-13) Mykhailiuk, Mykhailo Mykhailovich; Verbytski, Yevhenii Eduardovych
In our opinion, the main condition for the successful activity of a modern teacher is to focus on communication as one of the leading basic needs of the individual, since a person is part of society. It is also important to take into account the priorities that keep communication in the team (interests, motivations, preferences, assessments, value orientations of each student, group of students, teacher and university staff as a whole). The central person in the chain of communicative interactions is the teacher, because it is on him or her that a positive dialogue depends, which leads to high-quality professional interaction in the educational process. The dominant skill will be the ability to conduct a dialogue, organize the process of positive friendly communication, communication (the ability to listen, understand, explain, prove, ask and answer, persuade, create a creative atmosphere of trust and understanding, find an approach to special problems, relieve tension that may arise from time to time depending on the complexity of the tasks, resolve a conflict situation, and ultimately be sensitive to students who experience difficult conditions of uncertainty of the future in different ways, etc.) The solution to any pedagogical issue is possible only through communication and two-way pedagogical interaction. In today's context, it is important for a modern teacher to have in-depth knowledge of the age psychology and physiology of students, as well as to have psychological and didactic methods that help the teacher find the most effective mechanisms of communication interactions. This allows to stimulate creative work, choose technologies, forms and methods of interaction based on constructive dialogue based on the principle of partnership. And it is partnership, not familiarity.
Comparative analysis of concepts associations of "health" and "disease" among young people in Germany and high school students in Ukraine
(Baltija Publishing, 2022-07-30) Korniienko, O. V; Корнієнко, Олексій Васильович
The publication presents a cross-cultural comparative analysis of conceptual associations related to "health" and "disease" among young people in Germany (aged 13–25) and high school students in Ukraine. Based on empirical research, the study identifies similarities and key differences in adolescent health perceptions, highlighting the specific psychosomatic and valeological behaviors to promote a healthy lifestyle. У публікації представлено крос-культурний порівняльний аналіз концептуальних асоціацій, пов'язаних із поняттями "здоров'я" та "хвороба" серед молоді в Німеччині (віком 13–25 років) та старшокласників в Україні. На основі емпіричних даних визначено схожі риси та ключові відмінності у сприйнятті здоров'я підлітками, а також окреслено особливості психосоматичної та валеологічної поведінки для формування свідомої мотивації до здорового способу життя.
Comprehensive individualy-typological (ambivertive) and factor comparative analysis of psychosomatic health of boy and girl students of Kyiv National Taras Schevchenko University
(Science and Education a New Dimension. Pedagogy and Psychology, 2015-11) Korniienko, Oleksiy; Корнієнко, Олексій Васильович
The article presents a comprehensive study of the individual-typological and factor characteristics of psychosomatic health among students. Based on H. Eysenck's personality theory, the author conducts a comparative analysis of boy and girl students, specifically focusing on the ambivertive type. The research identifies key correlations between psychological personality traits and the state of psychosomatic well-being in the academic environment of Kyiv National Taras Shevchenko University. У статті представлено комплексне дослідження індивідуально-типологічних та факторних характеристик психосоматичного здоров’я студентів. На основі теорії особистості Г. Айзенка автор проводить порівняльний аналіз показників юнаків та дівчат, приділяючи особливу увагу амбівертивному типу. Дослідження виявляє ключові кореляції між психологічними рисами особистості та станом психосоматичного благополуччя в академічному середовищі Київського національного університету імені Тараса Шевченка.
Depressive neurosis as a factor disorders of psychosomatic health of girl and boy students of Kiev National Taras Shevchenko University
(Science and Education a New Dimension. Pedagogy and Psychology (Budapest, Hungary), 2016-01-15) Korniienko, Oleksiy; Корнієнко, Олексій Васильович
The article presents the results of the research of the dynamics of depressive and neurosis states of 686 students (375 girls and 311 boys) of Kyiv National Taras Shevchenko University during 2006–2009. The role of H. Eysenck’s theory of personality (extraversion/introversion, emotional stability/lability) in the formation of psychosomatic health of students is confirmed. It was found that for girls a "depressive-neurotic state of a melancholy direction" is characteristic, while for boys a similar state with expressed "somatically-oriented bodily complaints" is typical. The study emphasizes the importance of psychodiagnostics in monitoring the psychosomatic health indicators of students. У статті представлено результати дослідження динаміки депресивних та невротичних станів 686 студентів (375 дівчат та 311 юнаків) Київського національного університету імені Тараса Шевченка протягом 2006–2009 років. Підтверджено роль теорії особистості Г. Айзенка (екстраверсія/інтроверсія, емоційна стабільність/лабільність) у формуванні психосоматичного здоров’я студентів. Встановлено, що для дівчат характерний «депресивно-невротичний стан меланхолійного спрямування», тоді як для юнаків типовим є аналогічний стан із вираженими «соматично-орієнтованими тілесними скаргами». Дослідження підкреслює важливість психодіагностики в моніторингу показників психосоматичного здоров’я студентів.
Distance Learning for a Foreign Language in the Postmodern Age and its Forms.
(Postmodern Openings, 2021, Volume 12, Issue 2, pages: 339-353., 2021) Yuri Stezhko; Nadiia GRYTSYK; Maryna MYKHAILIUK; Hanna TEKLIUK; Olha RUSAVSKA5; Olga BEREGOVA
The article is devoted to innovative postmodern requests for the liberalization of education. Postmodernism influenced education not only methodologically, but also by changing the very pedagogical culture of teaching. Now the relevance of the research topic is due to the problems of forming information content and methodological support for the introduction of distance learning technology in mobile form. The introduction of IT in education, the improvement of smart devices, the formation of an electronic information and educational environment have created the basis for such forms of education as mobile learning and blended learning. In both cases, the student situationally himself forms the educational process, turns from an object of training into its subject. The humanistic potential of mobile learning in the sense of ensuring equal access to education for people with different abilities is noted. The opinion is expressed about the importance of student motivation and IT competence of teachers to provide information content, intensify the introduction of e-learning and mobile-oriented learning technologies. It is argued that learning based only on mobile learning technology, using smart devices without classroom or office work, real communication with the teacher is not didactically self-sufficient, which would provide adequate language skills. Effectiveness in learning foreign languages is achieved by synergy of technologies distance mobile and traditional classroom or classroom training, real communication with the teacher.
Echinacea Angustifolia and its influence on SARS viruses
(Київський медичний університет, 2022) Kolinko, Y.I
Introduction: Coronavirus or Covid 19 is a type of acute respiratory syndrome with a viral agent of the coronavirus family that causes lung disease, inflammation and apoptosis in humans and sometimes causes death in humans with weakened immune system. In this article, the active ingredients of Echinacea plant, which increases the resistance of the body's immune system and, which ultimately leads to the prevention and treatment of disease, have been studied.
EMOTIONAL IMPACT OF THE COVID-19 PANDEMIC ON HEALTHCARE WORKERS IN UKRAINE
(Aluna Publishing, 2022-05) Pinchuk Irina; Pishel Vitaliy; Polyvіanaia Marina; Kopchak Oksana; Chumak Stanislav; Filimonova Natalia; Yachnik Yuliaya
Objective: The aim: To study the emotional impact of the COVID-19 pandemic on healthcare workers in Ukraine. Patients and methods: Materials and methods: 1087 healthcare workers across all regions of Ukraine completed an online questionnaire. Respondents were divided into two groups: A - 863 (79.4%), В - 224 (20.6%), according to whether or not they experienced anxiety/fear related to COVID-19. Results: Results: Such factors as risk of contracting COVID-19, news of new cases, insufficient staff in healthcare facilities, risk of transmission of COVID-19 to family or friends, risk of death from COVID-19, the threat of the spread of the COVID-19 pandemic were associated with high level of anxiety/fear among healthcare workers. Factors that facilitate coping with stress included absence of Covid-19 cases among staff, recovering patients, availability of gear and protective equipment and absence of COVID-19 infected among loved ones, relieving stress (relaxation, going info sports and so on), communication with family and friends to relieve stress and get support, avoidance of COVID-19 media reports in particular on deaths connected cases, getting information about the spread of Covid-19 only from legitimate sources. Conclusion: Conclusions: The data obtained in this study indicate an urgent need for the development and implementation of preventive and rehabilitation measures aimed at stabilizing the psycho-emotional state of health workers and improving the quality of care in the special conditions of the COVID-19 pandemic. Achieving these goals will be facilitated by taking into account the specifics of the response to COVID-19 and measures to reduce the effects of stress while enhancing the effects of stressors among health care workers.
Evidence-Based Medicine” for medical students Kyiv Medical University with active participation in teacher’s Facebook page “Individual-Psychological war of Ukraine against Russia"
(Видавничий дім «Гельветика»., 2022-06-21) Корнієнко, Олексій Васильович; Korniienko, Oleksiy
The theses are devoted to the experience of teaching the discipline "Evidence-Based Medicine" for international students of Kyiv Medical University in the conditions of distance learning in 2022. The author describes the structure of the course using the Google Classroom platform and the integration of the Facebook social network to inform students about the real events of the war in Ukraine through the created group "Individual-Psychological war of Ukraine against Russia". Тези присвячені досвіду викладання дисципліни «Доказова медицина» для іноземних студентів КМУ в умовах дистанційного навчання у 2022 році. Автор описує структуру курсу з використанням платформи Google Classroom та інтеграцію соціальної мережі Facebook для інформування студентів про реальні події війни в Україні через створену групу «Індивідуально-психологічна війна України проти Росії».
Experience of classroom and distance teaching combination: basic disciplines, medical psychology, evidence-based medicine, career management for Ukrainian and foreign university students (2018-2022years).
(Liha-Pres, 2022-11-25) Корнієнко, Олексій Васильович; Korniienko, Oleksiy
The theses summarize the author's personal experience (2018–2022) of combining classroom and distance learning for Ukrainian and foreign medical students at Taras Shevchenko National University of Kyiv and Kyiv Medical University. It highlights the practical application of modern educational technologies, specifically the use of Facebook groups for teaching "Medical Psychology" to students from various countries (including India, Iran, South Korea, Egypt, etc.), as well as the implementation of Google Classroom for the "Evidence-Based Medicine" course during the second semester of 2022. The effectiveness of these platforms in maintaining student engagement and psychosomatic health is evaluated. У тезах узагальнено особистий досвід автора (2018–2022 рр.) щодо поєднання аудиторного та дистанційного навчання українських та іноземних студентів-медиків у Київському національному університеті імені Тараса Шевченка та Київському медичному університеті. Висвітлено практичне застосування сучасних освітніх технологій, зокрема використання навчальних груп у мережі Facebook для викладання «Медичної психології» студентам із різних країн світу (Індія, Іран, Південна Корея, Єгипет та ін.), а також впровадження платформи Google Classroom для курсу «Доказова медицина» протягом другого семестру 2022 року. Оцінено ефективність цих платформ для підтримки залученості та психосоматичного здоров'я студентів.
Experience of teaching "Evidence Based Medicine", "Medical Psychology", "Career Management" for third year medical students Kyiv Medical University with active participation in teacher's Facebook page "Individual-psychological war of Ukraine against Russia"
(ПВНЗ «Київський медичний університет» / PHEI "Kyiv Medical, 2022-11-30) Korniienko, Oleksiy; Корнієнко, Олексій Васильович
The theses describe the experience and goals of teaching "Evidence-Based Medicine", "Medical Psychology", and "Career Management" for third-year foreign medical students at Kyiv Medical University. The educational process integrates distance learning platforms (Google Classroom, Google Meet) with social media (Facebook) to enhance communication, discuss relevant topics, and systematically analyze students' views on contemporary challenges. У тезах висвітлено досвід та мету викладання дисциплін «Доказова медицина», «Медична психологія» та «Управління кар'єрою» для іноземних студентів-медиків третього курсу Київського медичного університету. Освітній процес успішно поєднує платформи дистанційного навчання (Google Classroom, Google Meet) із можливостями соціальних мереж (Facebook). Це дозволяє покращити комунікацію, обговорювати актуальні суспільні та професійні теми, а також систематично аналізувати погляди студентів на сучасні виклики та інформаційно-психологічні аспекти.
Facebook як платформа аудиторного/дистанційного викладання/навчання (особистий досвід 2018–2021 років)
(Baltija Publishing, 2021-07-17) Корнієнко, Олексій Васильович; Korniienko, Oleksiy
У тезах представлено особистий досвід автора (1994–2021 рр.) щодо впровадження очно-дистанційної концепції навчання на факультеті психології КНУ імені Тараса Шевченка. Розкрито етапи використання платформи Facebook у 2018–2021 роках для створення 22 навчальних груп з різних дисциплін («Безпека життєдіяльності», «Медична психологія» та ін.). Автор аналізує переваги поєднання аудиторних занять із інтерактивним діалогом у соцмережах для підвищення професійних компетенцій студентів. The abstract presents the author's personal experience (1994–2021) in implementing the full-time and distance learning concept at the Faculty of Psychology of Taras Shevchenko National University of Kyiv. The stages of using the Facebook platform in 2018–2021 to create 22 study groups in various disciplines are revealed. The author analyzes the advantages of combining classroom lessons with interactive dialogue in social networks to increase the professional competencies of students.
FEATURES OF GUT MICROBIOTA IN PATIENTS WITH MIGRAINE AND HEALTHY INDIVIDUALS
(Tbilisi State Medical University, 2022) Kopchak O.; Hrytsenko O.
The gut – brain axis plays a significant role in the pathophysiology of migraine. This interaction can be influenced by multiple factors, such as gut microbiota profiles. Background/Objectives: The aim of the study was to analyze the gut microbiome state in patients with migraine and healthy individuals, to assess possible correlations between the detected changes in patients with migraine and the frequency, intensity of headaches, their psycho-emotional state, and quality of life. Subjects/Methods: In total, 112 patients-16.3% of men and 83.7% of women. Subjects were divided into 2 groups depending on the presence of migraine: the main - patients with chronic and episodic forms of migraine, the control - healthy individuals. The study of the intestinal microbiome was performed by chromato-mass spectrometry. The following scales were used: Visual Analogue Scale/VAS, Migraine Disability Assessment/ MIDAS, Back Depression Inventory/BDI. Results: In patients with migraine compared with healthy individuals, significant changes were noted in the quantitative composition of certain resident microorganisms including Alcaligenes spp (p=0.0061), Clostridium coccoides (p=0.0021), Clostridium propionicum (p=0.0287), Eggerthella lenta (p=0.0138), Pseudonocardia spp (p=0.0210), and Rhodococcus spp (p=0.0164). The number of microscopic fungi such as Candida spp (p=0.0079), Micromycetes spp (p=0.0011) and Micromycetes spp (p=0.0010) were increased in patients with migraine compared to the control group. In the main group, a negative correlation was found between the level of Alcaligenes spp and the score on the BDI score, HARS score (respectively: r= -0.6226, p= 0.007; r= -0.509, p=0.03), the frequency of attacks (r=-0.4879, p=0.046) and the VAS score (r=-0.487, p=0.046). Significant negative correlation was found between elevated level of Clostridium coccoides and MIDAS score (r=-0.5123, p=0.03), BDI score (r=-0.54, p=0.025) in the patients with migraine. At the same time, in the main group a positive correlation was detected between Eggerthella lenta level of and VAS score (r=0.4830, p=0.049). In the main group negative correlations were found between slightly increased content of endotoxin in the main group, the BDI score, HARS score (respectively: r=-0.697, p=0.001; r=-0.557, p=0.02) the frequency of attacks (r=-0.547, p=0.023), on the VAS score (r=-0.531, p=0.028), as well as MIDAS score (r =-0.556, p=0.02). Conclusion: The revealed peculiarities of gut microbiome changes in patients with migraines need further clarification in order to identify the possible role of the gut microbiome in the pathogenesis, clinical picture, and therapy of migraine, and is a promising area of further scientific research.

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